Novel angiotensin II inhibitors in cardiovascular medicine.

Details

Serval ID
serval:BIB_6BB0A4D82985
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Novel angiotensin II inhibitors in cardiovascular medicine.
Journal
Expert opinion on investigational drugs
Author(s)
Burnier M.
ISSN
1354-3784
Publication state
Published
Issued date
2001
Peer-reviewed
Oui
Volume
10
Number
11
Pages
1957-64
Language
english
Notes
Publication types: Journal Article ; Review - Publication Status: ppublish
Abstract
Blockade of the renin-angiotensin-aldosterone cascade is now recognised as a very effective approach to treat hypertensive, heart failure and high cardiovascular risk patients and to retard the development of renal failure. The purpose of this review is to discuss the state of development of currently available drugs blocking the renin-angiotensin system, such as angiotensin converting enzyme (ACE) inhibitors, renin inhibitors and angiotensin II receptor antagonists, with a special emphasis on the results of the most recent trials conducted with AT(2) receptor antagonists in heart failure and Type 2 diabetes. In addition, the future perspectives of drugs with dual mechanisms of action, such as NEP/ACE inhibitors, also named vasopeptidase inhibitors, are presented.
Keywords
Angiotensin II, Angiotensin-Converting Enzyme Inhibitors, Animals, Cardiovascular Agents, Cardiovascular Diseases, Clinical Trials as Topic, Humans, Protease Inhibitors, Receptors, Angiotensin, Renin
Pubmed
Web of science
Create date
25/01/2008 12:55
Last modification date
20/08/2019 14:25
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