Article: article from journal or magazin.
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Novel angiotensin II inhibitors in cardiovascular medicine.
Expert opinion on investigational drugs
Publication types: Journal Article ; Review - Publication Status: ppublish
Blockade of the renin-angiotensin-aldosterone cascade is now recognised as a very effective approach to treat hypertensive, heart failure and high cardiovascular risk patients and to retard the development of renal failure. The purpose of this review is to discuss the state of development of currently available drugs blocking the renin-angiotensin system, such as angiotensin converting enzyme (ACE) inhibitors, renin inhibitors and angiotensin II receptor antagonists, with a special emphasis on the results of the most recent trials conducted with AT(2) receptor antagonists in heart failure and Type 2 diabetes. In addition, the future perspectives of drugs with dual mechanisms of action, such as NEP/ACE inhibitors, also named vasopeptidase inhibitors, are presented.
Angiotensin II, Angiotensin-Converting Enzyme Inhibitors, Animals, Cardiovascular Agents, Cardiovascular Diseases, Clinical Trials as Topic, Humans, Protease Inhibitors, Receptors, Angiotensin, Renin
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