Osmoregulation during Long-Term Fasting in Lungfish and Elephant Seal: Old and New Lessons for the Nephrologist.

Details

Serval ID
serval:BIB_6B552774823B
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Osmoregulation during Long-Term Fasting in Lungfish and Elephant Seal: Old and New Lessons for the Nephrologist.
Journal
Nephron
Author(s)
Rossier B.C.
ISSN
2235-3186 (Electronic)
ISSN-L
1660-8151
Publication state
Published
Issued date
2016
Peer-reviewed
Oui
Volume
134
Number
1
Pages
5-9
Language
english
Notes
Publication types: Journal Article ; Review
Publication Status: ppublish
Abstract
Vertebrates control the osmolality of their extra- and intra-cellular compartments despite large variations in salt and water intake. Aldosterone-dependent sodium reabsorption and vasopressin-dependent water transport in the distal nephron and collecting duct play a critical role in the final control of sodium and water balance. Long-term fasting (no eating, no drinking) represents an osmotic challenge for survival. Evolution has found very different solutions to meet this challenge. To illustrate this point, I will discuss osmoregulation of a mammal (elephant seal pup) and of a fish (lungfish) that are able to survive long-term fasting for months or even years. Homer W. Smith taught us how informative comparative anatomy and physiology of the kidney could help physiologists and nephrologists to better understand how the kidney works. In recent years, comparative genomics, transcriptomics and proteomics across the tree of life have led to the emergence of a new discipline, evolutionary medicine. In the near future, physiologists and nephrologists will benefit from this new field of investigation, thanks to its potential for the identification of novel drug targets and therapies.

Keywords
Animals, Arginine Vasopressin/physiology, Biological Evolution, Fasting, Fishes/physiology, Osmoregulation, Renin-Angiotensin System, Seals, Earless/physiology
Pubmed
Open Access
Yes
Create date
16/02/2016 18:31
Last modification date
17/09/2020 9:18
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