Combined adenocarcinoma–atypical carcinoid of the lung. Targeted Next-Generation Sequencing (NGS) suggests a monoclonal origin of the two components

Details

Serval ID
serval:BIB_6B2FC485CF3D
Type
Article: article from journal or magazin.
Publication sub-type
Case report (case report): feedback on an observation with a short commentary.
Collection
Publications
Institution
Title
Combined adenocarcinoma–atypical carcinoid of the lung. Targeted Next-Generation Sequencing (NGS) suggests a monoclonal origin of the two components
Journal
Diagnostic Histopathology
Author(s)
La Rosa S., Simbolo M., Franzi F., Uccella S., Imperatori A., Nardecchia E., Rotolo N., Dominioni L., Scarpa A., Sessa F.
ISSN
1756-2317
ISSN-L
1756-2317
Publication state
Published
Issued date
03/2018
Peer-reviewed
Oui
Volume
24
Number
3
Pages
120-123
Language
english
Abstract
Combined neoplasms of the lung are defined by the WHO classification as an admixture of a small or large cell neuroendocrine carcinoma and a non-neuroendocrine component. However, rare cases of carcinoids combined with a non-neuroendocrine component have been described. These tumor types are not included as a specific entity in the WHO classification of pulmonary neoplasms and their pathogenesis is still unknown. We describe the clinico-pathologic and molecular features of a mixed (combined) lung neoplasm composed of adenocarcinoma and atypical carcinoid. The NGS analysis of the two different tumor components shows a similar molecular profile suggesting their monoclonal origin from a transformed stem/progenitor tumor cell which acquires a divergent differentiation during its development and progression. We also suggest the use of the recently proposed term of mixed neuroendocrine/non-neuroendocrine neoplasm (MiNEN) to define mixed (combined) neoplasms of the lung, because it seems to better cover the wide spectrum of different possible combinations of neuroendocrine and non-neuroendocrine components.
Keywords
adenocarcinoma, carcinoid, combined neoplasm, lung, mixed neoplasm, monoclonality, Pathology and Forensic Medicine, Histology
Create date
27/03/2018 16:22
Last modification date
20/08/2019 14:25
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