Combined adenocarcinoma–atypical carcinoid of the lung. Targeted Next-Generation Sequencing (NGS) suggests a monoclonal origin of the two components

Détails

ID Serval
serval:BIB_6B2FC485CF3D
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Etude de cas (case report): rapporte une observation et la commente brièvement.
Collection
Publications
Titre
Combined adenocarcinoma–atypical carcinoid of the lung. Targeted Next-Generation Sequencing (NGS) suggests a monoclonal origin of the two components
Périodique
Diagnostic Histopathology
Auteur(s)
La Rosa S., Simbolo M., Franzi F., Uccella S., Imperatori A., Nardecchia E., Rotolo N., Dominioni L., Scarpa A., Sessa F.
ISSN
1756-2317
ISSN-L
1756-2317
Statut éditorial
Publié
Date de publication
03/2018
Peer-reviewed
Oui
Volume
24
Numéro
3
Pages
120-123
Langue
anglais
Résumé
Combined neoplasms of the lung are defined by the WHO classification as an admixture of a small or large cell neuroendocrine carcinoma and a non-neuroendocrine component. However, rare cases of carcinoids combined with a non-neuroendocrine component have been described. These tumor types are not included as a specific entity in the WHO classification of pulmonary neoplasms and their pathogenesis is still unknown. We describe the clinico-pathologic and molecular features of a mixed (combined) lung neoplasm composed of adenocarcinoma and atypical carcinoid. The NGS analysis of the two different tumor components shows a similar molecular profile suggesting their monoclonal origin from a transformed stem/progenitor tumor cell which acquires a divergent differentiation during its development and progression. We also suggest the use of the recently proposed term of mixed neuroendocrine/non-neuroendocrine neoplasm (MiNEN) to define mixed (combined) neoplasms of the lung, because it seems to better cover the wide spectrum of different possible combinations of neuroendocrine and non-neuroendocrine components.
Mots-clé
adenocarcinoma, carcinoid, combined neoplasm, lung, mixed neoplasm, monoclonality, Pathology and Forensic Medicine, Histology
Création de la notice
27/03/2018 16:22
Dernière modification de la notice
20/08/2019 14:25
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