Decreasing Insulin Sensitivity in Women Induces Alterations in LH Pulsatility.

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Version: Author's accepted manuscript
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Serval ID
serval:BIB_6ABDC9754261
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Decreasing Insulin Sensitivity in Women Induces Alterations in LH Pulsatility.
Journal
The Journal of clinical endocrinology and metabolism
Author(s)
van Leckwyck M., Kong W., Burton K.J., Amati F., Vionnet N., Pralong F.P.
ISSN
1945-7197 (Electronic)
ISSN-L
0021-972X
Publication state
Published
Issued date
08/2016
Peer-reviewed
Oui
Volume
101
Number
8
Pages
3240-3249
Language
english
Notes
Publication types: Clinical Trial ; Journal Article
Publication Status: ppublish
Abstract
Obesity is associated with neuroendocrine reproductive alterations and decreased fertility.
The objective of the study was to gain insight into the neuroendocrine mechanisms implicated in these alterations.
The effects on pulsatile LH secretion of 28 days of a hypercaloric diet were studied in lean and regularly cycling female volunteers. Approximately 50% extra calories (3 g sucrose/kg body weight per day and 1 g fat/kg body weight per day) were added to their individual daily requirements. Spontaneous and insulin-stimulated LH secretion was recorded on 2 different days, before and at the end of the caloric load.
The hypercaloric diet induced an average weight gain of 2.0 ± 0.3 kg (P < .05), corresponding to a body mass index increase of 0.7 ± 0.1 kg/m(2) (P < .05). A concomitant decrease of 11.6% ± 4.6% in whole-body insulin sensitivity was also observed (δ = -1.6 ± 0.7 mg/kg · min glucose; P < .05). The frequency of spontaneous and insulin-stimulated pulsatile LH secretion was increased by 17.9% ± 9.0% and 26.5% ± 9.0%, respectively (both P < .05). Spontaneous LH peak amplitude was decreased by 26.5% ± 9.0% (δ = -0.7 ± 0.36 U/L; P < .05), a change correlated with insulin sensitivity.
Short-term weight gain in normal female volunteers induces alterations of LH secretion reminiscent to those observed in obesity. A decrease in insulin sensitivity may constitute a mechanistic link between obesity and its associated neuroendocrine dysfunctions.
Keywords
Adolescent, Adult, Diet, Atherogenic, Diet, High-Fat, Feeding Behavior/physiology, Female, Humans, Infertility, Female/blood, Infertility, Female/etiology, Insulin Resistance/physiology, Luteinizing Hormone/blood, Luteinizing Hormone/secretion, Obesity/blood, Obesity/complications, Young Adult
Pubmed
Web of science
Open Access
Yes
Funding(s)
Swiss National Science Foundation / Careers / PZ00P3-149398
Create date
24/06/2016 11:06
Last modification date
20/01/2020 7:20
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