Natural History of Myocardial α<sub>v</sub>β<sub>3</sub> Integrin Expression After Acute Myocardial Infarction: Correlation with Changes in Myocardial Blood Flow.

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Version: Final published version
License: CC BY 4.0
Serval ID
serval:BIB_6979E661C78F
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Natural History of Myocardial α<sub>v</sub>β<sub>3</sub> Integrin Expression After Acute Myocardial Infarction: Correlation with Changes in Myocardial Blood Flow.
Journal
Journal of nuclear medicine
Author(s)
Dietz M., Kamani C.H., Bousige C., Dunet V., Delage J., Rubimbura V., Nicod Lalonde M., Treglia G., Schaefer N., Nammas W., Saraste A., Knuuti J., Mewton N., Prior J.O.
ISSN
1535-5667 (Electronic)
ISSN-L
0161-5505
Publication state
In Press
Peer-reviewed
Oui
Language
english
Notes
Publication types: Journal Article
Publication Status: aheadofprint
Abstract
Angiogenesis is an essential part of the cardiac repair process after myocardial infarction, but its spatiotemporal dynamics remain to be fully deciphered. <sup>68</sup> Ga-NODAGA-Arg-Gly-Asp (RGD) is a PET tracer targeting α <sub>v</sub> β <sub>3</sub> integrin expression, which is a marker of angiogenesis. Methods: In this prospective single-center trial, we aimed to monitor angiogenesis through myocardial integrin α <sub>v</sub> β <sub>3</sub> expression in 20 patients with ST-segment elevation myocardial infarction (STEMI). In addition, the correlations between the expression levels of myocardial α <sub>v</sub> β <sub>3</sub> integrin and the subsequent changes in <sup>82</sup> Rb PET/CT parameters, including rest and stress myocardial blood flow (MBF), myocardial flow reserve (MFR), and wall motion abnormalities, were assessed. The patients underwent <sup>68</sup> Ga-NODAGA-RGD PET/CT and rest and stress <sup>82</sup> Rb-PET/CT at 1 wk, 1 mo, and 3 mo after STEMI. To assess <sup>68</sup> Ga-NODAGA-RGD uptake, the summed rest <sup>82</sup> Rb and <sup>68</sup> Ga-NODAGA-RGD images were coregistered, and segmental SUVs were calculated (RGD SUV). Results: At 1 wk after STEMI, 19 participants (95%) presented increased <sup>68</sup> Ga-NODAGA-RGD uptake in the infarcted myocardium. Seventeen participants completed the full imaging series. The values of the RGD SUV in the infarcted myocardium were stable 1 mo after STEMI (1 wk vs. 1 mo, 1.47 g/mL [interquartile range (IQR), 1.37-1.64 g/mL] vs. 1.47 g/mL [IQR, 1.30-1.66 g/mL]; P = 0.9), followed by a significant partial decrease at 3 mo (1.32 g/mL [IQR, 1.12-1.71 g/mL]; P = 0.011 vs. 1 wk and 0.018 vs. 1 mo). In segment-based analysis, positive correlations were found between RGD SUV at 1 wk and the subsequent changes in stress MBF (Spearman ρ: r = 0.17, P = 0.0033) and MFR (Spearman ρ: r = 0.31, P < 0.0001) at 1 mo. A negative correlation was found between RGD SUV at 1 wk and the subsequent changes in wall motion abnormalities at 3 mo (Spearman ρ: r = -0.12, P = 0.035). Conclusion: The present study found that α <sub>v</sub> β <sub>3</sub> integrin expression is significantly increased in the infarcted myocardium 1 wk after STEMI. This expression remains stable after 1 mo and partially decreases after 3 mo. Initial α <sub>v</sub> β <sub>3</sub> integrin expression at 1 wk is significantly weakly correlated with subsequent improvements in stress MBF, MFR, and wall motion analysis.
Keywords
PET, RGD, angiogenesis, integrin αvβ3, myocardial infarction
Pubmed
Open Access
Yes
Create date
13/05/2024 14:32
Last modification date
05/06/2024 8:23
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