Language Regression Associated With Autistic Regression and Electroencephalographic (EEG) Abnormalities: A Prospective Study.

Details

Serval ID
serval:BIB_694F71738CDF
Type
Article: article from journal or magazin.
Publication sub-type
Case report (case report): feedback on an observation with a short commentary.
Collection
Publications
Title
Language Regression Associated With Autistic Regression and Electroencephalographic (EEG) Abnormalities: A Prospective Study.
Journal
Journal of Child Neurology
Author(s)
Chilosi A.M., Brovedani P., Ferrari A.R., Ziegler A.L., Guerrini R., Deonna T.
ISSN
1708-8283 (Electronic)
ISSN-L
0883-0738
Publication state
Published
Issued date
2013
Peer-reviewed
Oui
Volume
29
Number
6
Pages
855-859
Language
english
Notes
Publication types: ARTICLE
Abstract
We report a boy, referred at 25 months following a dramatic isolated language regression antedating autistic-like symptomatology. His sleep electroencephalogram (EEG) showed persistent focal epileptiform activity over the left parietal and vertex areas never associated with clinical seizures. He was started on adrenocorticotropic hormone (ACTH) with a significant improvement in language, behavior, and in EEG discharges in rapid eye movement (REM) sleep. Later course was characterized by fluctuations/regressions in language and behavior abilities, in phase with recrudescence of EEG abnormalities prompting additional ACTH courses that led to remarkable decrease in EEG abnormalities, improvement in language, and to a lesser degree, in autistic behavior. The timely documentation of regression episodes suggesting an "atypical" autistic regression, striking therapy-induced improvement, fluctuation of symptomatology over time could be ascribed to recurrent and persisting EEG abnormalities.
Pubmed
Web of science
Create date
05/09/2014 17:20
Last modification date
20/08/2019 14:24
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