Measurement of pancreatic stone protein in the identification and management of sepsis.

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State: Public
Version: Final published version
License: CC BY-NC-ND 4.0
Serval ID
serval:BIB_6894DEBEEC4E
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Measurement of pancreatic stone protein in the identification and management of sepsis.
Journal
Biomarkers in medicine
Author(s)
Eggimann P., Que Y.A., Rebeaud F.
ISSN
1752-0371 (Electronic)
ISSN-L
1752-0363
Publication state
Published
Issued date
02/2019
Peer-reviewed
Oui
Volume
13
Number
2
Pages
135-145
Language
english
Notes
Publication types: Journal Article ; Review
Publication Status: ppublish
Abstract
Sepsis is a life-threatening syndrome characterized by a dysregulated host response to an infection resulting in multiple organ dysfunctions. Early diagnosis and management of sepsis is key to improve patient outcome but remains challenging. Despite extensive research, only few biomarkers have so far proven to be helpful in the diagnosis of sepsis. A novel protein biomarker, the pancreatic stone protein (PSP), is showing great promises. Several lines of evidences suggest that PSP has a higher diagnostic performance for the identification of sepsis than procalcitonin and C-reactive protein, and a strong prognostic value to predict unfavorable outcome at admission to intensive care unit. This review summarizes the current knowledge on the molecular mechanisms of PSP function and the clinical evidences available to highlight the relevance of this protein in the diagnosis and prognosis of sepsis.
Keywords
Biomarkers/analysis, Biomarkers/metabolism, Humans, Lithostathine/analysis, Lithostathine/metabolism, Prognosis, ROC Curve, Sepsis/diagnosis, Sepsis/metabolism, PSP, diagnosis, diagnostics, infection, prognosis, sepsis
Pubmed
Web of science
Open Access
Yes
Create date
17/02/2019 16:12
Last modification date
11/01/2020 7:16
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