Eosinophilic aseptic arachnoiditis. A neurological complication in HIV-negative drug-addicts.

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Serval ID
serval:BIB_682279AC2A27
Type
Article: article from journal or magazin.
Publication sub-type
Case report (case report): feedback on an observation with a short commentary.
Collection
Publications
Institution
Title
Eosinophilic aseptic arachnoiditis. A neurological complication in HIV-negative drug-addicts.
Journal
Journal of neurology
Author(s)
Rossetti A.O., Meagher-Villemure K., Vingerhoets F., Maeder P., Bogousslavsky J.
ISSN
0340-5354
Publication state
Published
Issued date
2002
Peer-reviewed
Oui
Volume
249
Number
7
Pages
884-7
Language
english
Notes
Publication types: Case Reports ; Journal Article - Publication Status: ppublish
Abstract
The finding of an eosinophilic aseptic meningitis in IV drug abuse is usually suggestive of an opportunistic infection or an allergic reaction. However, HIV-negative patients are at lower risk for developing these complications. Two young HIV-negative patients, with previous intravenous polytoxicomany, developed cystic arachnoiditis over the spinal cord associated with eosinophilic meningitis. Histology of the meningeal spinal cord lesions revealed a vasculocentric mixed inflammatory reaction. In one patient prednisone led to marked clinical improvement. Since infection, vasculitis, sarcoidosis and previous myelography were ruled out, we believe that the syndrome of eosinophilic aseptic arachnoiditis may be related to an hyperergic reaction in the meniges toward drug-adulterants inoculated through the intravenous route.
Keywords
Adult, Anti-Inflammatory Agents, Arachnoiditis, Eosinophilia, Female, Humans, Male, Prednisone, Substance Abuse, Intravenous, Syndrome, Treatment Outcome
Pubmed
Web of science
Open Access
Yes
Create date
11/04/2008 8:23
Last modification date
01/10/2019 6:18
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