Occurrence and prognosis of lymph node metastases in patients selected for isolated limb perfusion with soft tissue sarcoma.

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Version: Final published version
License: CC BY-NC 4.0
Serval ID
serval:BIB_6786C75D78F3
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Occurrence and prognosis of lymph node metastases in patients selected for isolated limb perfusion with soft tissue sarcoma.
Journal
Journal of Cancer
Author(s)
Crettenand F., Martin D., Cherix S., Demartines N., Matter M.
ISSN
1837-9664 (Print)
ISSN-L
1837-9664
Publication state
Published
Issued date
2018
Peer-reviewed
Oui
Volume
9
Number
18
Pages
3311-3315
Language
english
Notes
Publication types: Journal Article
Publication Status: epublish
Abstract
<b>
<i>Background and Objectives:</i>
</b> Extensive surgery is often required for advanced soft tissue sarcoma (STS) of the limb. In the 1980s, a new approach was developed: isolated limb perfusion (ILP). This study aimed to assess incidence and impact on patient survival based on lymph node metastasis with systematic radical lymphadenectomy during ILP. <b>
<i>Methods:</i>
</b> Retrospective study of 57 consecutive patients treated by ILP for limb STS with simultaneous radical lymph node dissection in our tertiary referral center between 1992 and 2015. <b>
<i>Results:</i>
</b> Median age was 62 years (19-87) and 30 patients were male (53%). Lymph node involvement was observed in 13 patients (N1, 23%), regarded as metastatic spreading in 4 angiosarcomas, 3 epithelioid sarcomas, 2 leiomyosarcomas, 2 undifferentiated sarcomas and 2 synovial sarcomas. For the N0 patient group, median survival was 73.9 months (CI 95% 41.9-105.9) compared to 15.1 months (CI 95% 7.4-22.6) in case of metastatic lymph node ( <i>p</i> =0.002). The median disease-free survival was 33,0 months (CI 95% 12,5-53.5) in N0 group and 8.0 months (CI 95% 4.0-11.9) in N1 ( <i>p</i> =0.006). <b>
<i>Conclusions:</i>
</b> Lymph node metastases of STS patients selected for ILP seemed to have a negative impact on both overall and disease-free survival. Radical lymph node dissection should be included in ILP procedure.
Keywords
incidence, limb sarcoma, lymph node metastases, prognosis
Pubmed
Web of science
Open Access
Yes
Create date
05/10/2018 17:59
Last modification date
20/08/2019 15:23
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