Antiepileptic drugs modify power of high EEG frequencies and their neural generators.
Details
Serval ID
serval:BIB_668198173262
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Antiepileptic drugs modify power of high EEG frequencies and their neural generators.
Journal
European journal of neurology
ISSN
1468-1331 (Electronic)
ISSN-L
1351-5101
Publication state
Published
Issued date
10/2010
Peer-reviewed
Oui
Volume
17
Number
10
Pages
1308-1312
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Publication Status: ppublish
Abstract
The clinical and molecular effects of antiepileptic drugs (AEDs) have been extensively investigated. Much less is known about their effects on human electrophysiology.
Topographic analysis in the frequency domain has been used to analyze 104 electroencephalogram (EEG) epochs of 52 patients presenting with first-ever generalized seizure, with normal MRI and EEG. Patients were treated with valproate, arbamazepine, or lamotrigine in monotherapy (each group n = 13). Thirteen patients without medication served as a control group.
Carbamazepine and lamotrigine, both sodium-channel modulators, altered brain topography in the gamma range in the same frequency bands (50-60 Hz). Valproate, which has multiple actions on sodium and calcium channels as well as GABA turnover, modified brain topography in the low gamma range (30-40 Hz). No such changes were found in the control group. For all AEDs, the neural generators were shifted more anteriorly in medial temporal through to inferior frontal regions.
Decreased gamma-power and anterior shift of neural generators after AED introduction reflect AED influence on human electrophysiology.
Topographic analysis in the frequency domain has been used to analyze 104 electroencephalogram (EEG) epochs of 52 patients presenting with first-ever generalized seizure, with normal MRI and EEG. Patients were treated with valproate, arbamazepine, or lamotrigine in monotherapy (each group n = 13). Thirteen patients without medication served as a control group.
Carbamazepine and lamotrigine, both sodium-channel modulators, altered brain topography in the gamma range in the same frequency bands (50-60 Hz). Valproate, which has multiple actions on sodium and calcium channels as well as GABA turnover, modified brain topography in the low gamma range (30-40 Hz). No such changes were found in the control group. For all AEDs, the neural generators were shifted more anteriorly in medial temporal through to inferior frontal regions.
Decreased gamma-power and anterior shift of neural generators after AED introduction reflect AED influence on human electrophysiology.
Keywords
Adolescent, Adult, Anticonvulsants/pharmacology, Brain Waves/drug effects, Brain Waves/physiology, Carbamazepine/pharmacology, Electroencephalography/drug effects, Epilepsy/drug therapy, Epilepsy/pathology, Epilepsy/physiopathology, Female, Humans, Ion Channels/drug effects, Ion Channels/physiology, Lamotrigine, Male, Neurons/drug effects, Neurons/pathology, Triazines/pharmacology, Valproic Acid/pharmacology, Young Adult
Pubmed
Web of science
Create date
11/08/2023 14:49
Last modification date
03/10/2023 6:58
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