Antiepileptic drugs modify power of high EEG frequencies and their neural generators.

Détails

ID Serval
serval:BIB_668198173262
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Antiepileptic drugs modify power of high EEG frequencies and their neural generators.
Périodique
European journal of neurology
Auteur⸱e⸱s
Arzy S., Allali G., Brunet D., Michel C.M., Kaplan P.W., Seeck M.
ISSN
1468-1331 (Electronic)
ISSN-L
1351-5101
Statut éditorial
Publié
Date de publication
10/2010
Peer-reviewed
Oui
Volume
17
Numéro
10
Pages
1308-1312
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Résumé
The clinical and molecular effects of antiepileptic drugs (AEDs) have been extensively investigated. Much less is known about their effects on human electrophysiology.
Topographic analysis in the frequency domain has been used to analyze 104 electroencephalogram (EEG) epochs of 52 patients presenting with first-ever generalized seizure, with normal MRI and EEG. Patients were treated with valproate, arbamazepine, or lamotrigine in monotherapy (each group n = 13). Thirteen patients without medication served as a control group.
Carbamazepine and lamotrigine, both sodium-channel modulators, altered brain topography in the gamma range in the same frequency bands (50-60 Hz). Valproate, which has multiple actions on sodium and calcium channels as well as GABA turnover, modified brain topography in the low gamma range (30-40 Hz). No such changes were found in the control group. For all AEDs, the neural generators were shifted more anteriorly in medial temporal through to inferior frontal regions.
Decreased gamma-power and anterior shift of neural generators after AED introduction reflect AED influence on human electrophysiology.
Mots-clé
Adolescent, Adult, Anticonvulsants/pharmacology, Brain Waves/drug effects, Brain Waves/physiology, Carbamazepine/pharmacology, Electroencephalography/drug effects, Epilepsy/drug therapy, Epilepsy/pathology, Epilepsy/physiopathology, Female, Humans, Ion Channels/drug effects, Ion Channels/physiology, Lamotrigine, Male, Neurons/drug effects, Neurons/pathology, Triazines/pharmacology, Valproic Acid/pharmacology, Young Adult
Pubmed
Web of science
Création de la notice
11/08/2023 14:49
Dernière modification de la notice
03/10/2023 6:58
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