Influence of IFNL3/4 Polymorphisms on the Incidence of Cytomegalovirus Infection After Solid-Organ Transplantation.

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Ressource 1Download: serval:BIB_653026F3E5A8.P001 (331.14 [Ko])
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Version: author
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It was possible to publish this article open access thanks to a Swiss National Licence with the publisher.
Serval ID
serval:BIB_653026F3E5A8
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Influence of IFNL3/4 Polymorphisms on the Incidence of Cytomegalovirus Infection After Solid-Organ Transplantation.
Journal
Journal of Infectious Diseases
Author(s)
Manuel O., Wójtowicz A., Bibert S., Mueller N.J., van Delden C., Hirsch H.H., Steiger J., Stern M., Egli A., Garzoni C., Binet I., Weisser M., Berger C., Cusini A., Meylan P., Pascual M., Bochud P.Y.
Working group(s)
Swiss Transplant Cohort Study (STCS), Swiss Transplant Cohort Study STCS
Contributor(s)
Binet I., De Geest S., van Delden C., Hofbauer G., Huynh-Do U., Koller M., Lovis C., Manuel O., Meylan P., Mueller Nj., Pascual M., Schaub S., Steiger J.
ISSN
1537-6613 (Electronic)
ISSN-L
0022-1899
Publication state
Published
Issued date
2015
Volume
211
Number
6
Pages
906-914
Language
english
Notes
Publication types: Journal ArticlePublication Status: ppublish
Abstract
BACKGROUND: Polymorphisms in IFNL3 and IFNL4, the genes encoding interferon λ3 and interferon λ4, respectively, have been associated with reduced hepatitis C virus clearance. We explored the role of such polymorphisms on the incidence of cytomegalovirus (CMV) infection in solid-organ transplant recipients.
METHODS: White patients participating in the Swiss Transplant Cohort Study in 2008-2011 were included. A novel functional TT/-G polymorphism (rs368234815) in the CpG region upstream of IFNL3 was investigated.
RESULTS: A total of 840 solid-organ transplant recipients at risk for CMV infection were included, among whom 373 (44%) received antiviral prophylaxis. The 12-month cumulative incidence of CMV replication and disease were 0.44 and 0.08 cases, respectively. Patient homozygous for the minor rs368234815 allele (-G/-G) tended to have a higher cumulative incidence of CMV replication (subdistribution hazard ratio [SHR], 1.30 [95% confidence interval {CI}, .97-1.74]; P = .07), compared with other patients (TT/TT or TT/-G). The association was significant among patients followed by a preemptive approach (SHR, 1.46 [95% CI, 1.01-2.12]; P = .047), especially in patients receiving an organ from a seropositive donor (SHR, 1.92 [95% CI, 1.30-2.85]; P = .001), but not among those who received antiviral prophylaxis (SHR, 1.13 [95% CI, .70-1.83]; P = .6). These associations remained significant in multivariate competing risk regression models.
CONCLUSIONS: Polymorphisms in the IFNL3/4 region influence susceptibility to CMV replication in solid-organ transplant recipients, particularly in patients not receiving antiviral prophylaxis.
Pubmed
Web of science
Open Access
Yes
Create date
02/04/2015 20:26
Last modification date
25/09/2019 7:09
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