Drug resistance in Mycobacterium tuberculosis.

Details

Serval ID
serval:BIB_64895585D05C
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Drug resistance in Mycobacterium tuberculosis.
Journal
European Respiratory Journal. Supplement
Author(s)
Cole S.T., Telenti A.
ISSN
0904-1850[print], 0904-1850[linking]
Publication state
Published
Issued date
1995
Volume
20
Pages
701s-713s
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't ; Review Publication Status: ppublish
Abstract
During the last decade, there has been a marked increase in the number of gravity of tuberculosis cases both in developing countries and in industrialized nations. This is, in part, due to the acquired immune deficiency syndrome (AIDS) pandemic, but global economic depression, increased homelessness and declining control programmes have also contributed. One of the more insidious consequences of this resurgence has been the recent emergence and nosocomial transmission of multidrug-resistant strains of Mycobacterium tuberculosis, thus raising the possibility that untreatable forms of the disease may become widespread. Somewhat surprisingly, given the difficulties of working with this slow-growing pathogen, remarkable progress has been made in a relatively short time, in understanding the molecular epidemiology, the genetic basis, and the biochemical mechanisms of drug resistance. Furthermore, a number of promising molecular tools are now available to help counter tuberculosis and to further understanding.
Keywords
AIDS-Related Opportunistic Infections/drug therapy, AIDS-Related Opportunistic Infections/transmission, Amino Acid Sequence/genetics, Antitubercular Agents/therapeutic use, Cross Infection/drug therapy, Cross Infection/transmission, Developing Countries, Drug Resistance, Multiple/genetics, Humans, Microbial Sensitivity Tests, Molecular Sequence Data, Mycobacterium tuberculosis/drug effects, Mycobacterium tuberculosis/genetics, Polymerase Chain Reaction, Rifampin/therapeutic use, Risk Factors, Tuberculosis, Multidrug-Resistant/drug therapy, Tuberculosis, Multidrug-Resistant/transmission, Tuberculosis, Pulmonary/drug therapy, Tuberculosis, Pulmonary/transmission
Pubmed
Create date
25/01/2008 14:46
Last modification date
20/08/2019 14:20
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