Article: article from journal or magazin.
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Drug resistance in Mycobacterium tuberculosis.
European Respiratory Journal. Supplement
Publication types: Journal Article ; Research Support, Non-U.S. Gov't ; Review Publication Status: ppublish
During the last decade, there has been a marked increase in the number of gravity of tuberculosis cases both in developing countries and in industrialized nations. This is, in part, due to the acquired immune deficiency syndrome (AIDS) pandemic, but global economic depression, increased homelessness and declining control programmes have also contributed. One of the more insidious consequences of this resurgence has been the recent emergence and nosocomial transmission of multidrug-resistant strains of Mycobacterium tuberculosis, thus raising the possibility that untreatable forms of the disease may become widespread. Somewhat surprisingly, given the difficulties of working with this slow-growing pathogen, remarkable progress has been made in a relatively short time, in understanding the molecular epidemiology, the genetic basis, and the biochemical mechanisms of drug resistance. Furthermore, a number of promising molecular tools are now available to help counter tuberculosis and to further understanding.
AIDS-Related Opportunistic Infections/drug therapy, AIDS-Related Opportunistic Infections/transmission, Amino Acid Sequence/genetics, Antitubercular Agents/therapeutic use, Cross Infection/drug therapy, Cross Infection/transmission, Developing Countries, Drug Resistance, Multiple/genetics, Humans, Microbial Sensitivity Tests, Molecular Sequence Data, Mycobacterium tuberculosis/drug effects, Mycobacterium tuberculosis/genetics, Polymerase Chain Reaction, Rifampin/therapeutic use, Risk Factors, Tuberculosis, Multidrug-Resistant/drug therapy, Tuberculosis, Multidrug-Resistant/transmission, Tuberculosis, Pulmonary/drug therapy, Tuberculosis, Pulmonary/transmission
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