Cyclooxygenase-2 Expression in Non-Small Cell Lung Cancer Correlates With Hypertrophic Osteoarthropathy.

Details

Serval ID
serval:BIB_644807C95340
Type
Article: article from journal or magazin.
Publication sub-type
Case report (case report): feedback on an observation with a short commentary.
Collection
Publications
Institution
Title
Cyclooxygenase-2 Expression in Non-Small Cell Lung Cancer Correlates With Hypertrophic Osteoarthropathy.
Journal
Annals of Thoracic Surgery
Author(s)
Rotas I., Cito G., Letovanec I., Christodoulou M., Perentes J.Y.
ISSN
1552-6259 (Electronic)
ISSN-L
0003-4975
Publication state
Published
Issued date
2016
Peer-reviewed
Oui
Volume
101
Number
2
Pages
e51-e53
Language
english
Notes
Publication types: Case Reports ; Journal Article
Publication Status: ppublish
Abstract
Hypertrophic osteoarthrpathy (HO) is a rare paraneoplasic syndrome associated with non-small cell lung cancer (NSCLC). The pathophysiology of HO is unknown but was recently related to enhanced levels of urine prostaglandin E2 (PGE2). Here, we report the case of a patient that presented HO in association with a resectable left upper lobe NSCLC. Following surgery and adjuvant chemotherapy, HO resolved and did not recur with development of a brain metastasis 1 year later. Interestingly, tumor cyclooxygenase-2, an enzyme responsible the synthesis of PGE2, was expressed in the primary tumor but not in the resected metastasis.
Keywords
Aged, Carcinoma, Non-Small-Cell Lung/metabolism, Cyclooxygenase 2/biosynthesis, Humans, Lung Neoplasms/metabolism, Male, Osteoarthropathy, Secondary Hypertrophic/metabolism, Paraneoplastic Syndromes/metabolism
Pubmed
Web of science
Create date
20/01/2016 12:25
Last modification date
20/08/2019 14:20
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