Racial Differences in Cancer Susceptibility and Survival: More Than the Color of the Skin?

Details

Serval ID
serval:BIB_643866D47BDE
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Racial Differences in Cancer Susceptibility and Survival: More Than the Color of the Skin?
Journal
Trends in cancer
Author(s)
Özdemir B.C., Dotto G.P.
ISSN
2405-8025 (Electronic)
ISSN-L
2405-8025
Publication state
Published
Issued date
03/2017
Peer-reviewed
Oui
Volume
3
Number
3
Pages
181-197
Language
english
Notes
Publication types: Journal Article ; Review
Publication Status: ppublish
Abstract
Epidemiological studies point to race as a determining factor in cancer susceptibility. In US registries recording cancer incidence and survival by race (distinguishing 'black versus white'), individuals of African ancestry have a globally increased risk of malignancies compared with Caucasians and Asian Americans. Differences in socioeconomic status and health-care access play a key role. However, the lesser disease susceptibility of Hispanic populations with comparable lifestyles and socioeconomic status as African Americans (Hispanic paradox) points to the concomitant importance of genetic determinants. Here, we overview the molecular basis of racial disparity in cancer susceptibility ranging from genetic polymorphisms and cancer-driver gene mutations to obesity, chronic inflammation, and immune responses. We discuss implications for race-adapted cancer screening programs and clinical trials to reduce disparities in cancer burden.
Keywords
Asian Americans/genetics, Continental Population Groups/genetics, European Continental Ancestry Group/genetics, Genetic Predisposition to Disease, Healthcare Disparities, Hispanic Americans/genetics, Humans, Neoplasms/epidemiology, Neoplasms/genetics, Neoplasms/pathology, Social Class
Pubmed
Web of science
Create date
10/08/2017 9:52
Last modification date
20/08/2019 14:20
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