Lack of association of T cell receptor V beta 8 polymorphism with rheumatoid arthritis in United Kingdom and Italian white patients
Details
Serval ID
serval:BIB_63842857AB06
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Lack of association of T cell receptor V beta 8 polymorphism with rheumatoid arthritis in United Kingdom and Italian white patients
Journal
Annals of the Rheumatic Diseases
ISSN
0003-4967 (Print)
Publication state
Published
Issued date
05/1994
Volume
53
Number
5
Pages
341-3
Notes
Journal Article --- Old month value: May
Abstract
OBJECTIVES--To study if the reported association of a BamH I 2kb RFLP of the T cell receptor V beta 8 gene with DR4+ rheumatoid arthritis patients is found in non-American white populations. METHODS--The frequency of this RFLP in two different populations was analysed. Eighty one northern Italians were studied for HLA-DR genotypes and V beta 8 polymorphism, and 29 DR4+ British white patients were studied for V beta 8 polymorphism. RESULTS--No association between the V beta 8 RFLP and DR4 was found with rheumatoid arthritis in both groups. CONCLUSION--The reported V beta 8-DR4 association is not generally applicable. The lack of association in our populations may be due to genetic differences, or to differences in factors which shaped the T cell repertoire.
Keywords
Arthritis, Rheumatoid/*genetics
Genotype
Great Britain
HLA-DR1 Antigen/analysis
HLA-DR4 Antigen/analysis
Humans
Italy
Polymorphism, Genetic
Polymorphism, Restriction Fragment Length
Receptors, Antigen, T-Cell, alpha-beta/*genetics
Pubmed
Web of science
Open Access
Yes
Create date
25/01/2008 9:38
Last modification date
20/08/2019 15:20