Lack of association of T cell receptor V beta 8 polymorphism with rheumatoid arthritis in United Kingdom and Italian white patients

Details

Serval ID
serval:BIB_63842857AB06
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Lack of association of T cell receptor V beta 8 polymorphism with rheumatoid arthritis in United Kingdom and Italian white patients
Journal
Annals of the Rheumatic Diseases
Author(s)
Lunardi  C., Ibberson  M., Zeminian  S., De Sandre  G., So  A. K.
ISSN
0003-4967 (Print)
Publication state
Published
Issued date
05/1994
Volume
53
Number
5
Pages
341-3
Notes
Journal Article --- Old month value: May
Abstract
OBJECTIVES--To study if the reported association of a BamH I 2kb RFLP of the T cell receptor V beta 8 gene with DR4+ rheumatoid arthritis patients is found in non-American white populations. METHODS--The frequency of this RFLP in two different populations was analysed. Eighty one northern Italians were studied for HLA-DR genotypes and V beta 8 polymorphism, and 29 DR4+ British white patients were studied for V beta 8 polymorphism. RESULTS--No association between the V beta 8 RFLP and DR4 was found with rheumatoid arthritis in both groups. CONCLUSION--The reported V beta 8-DR4 association is not generally applicable. The lack of association in our populations may be due to genetic differences, or to differences in factors which shaped the T cell repertoire.
Keywords
Arthritis, Rheumatoid/*genetics Genotype Great Britain HLA-DR1 Antigen/analysis HLA-DR4 Antigen/analysis Humans Italy Polymorphism, Genetic Polymorphism, Restriction Fragment Length Receptors, Antigen, T-Cell, alpha-beta/*genetics
Pubmed
Web of science
Open Access
Yes
Create date
25/01/2008 8:38
Last modification date
20/08/2019 14:20
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