Oxytocin selectively gates fear responses through distinct outputs from the central amygdala.

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State: Public
Version: author
Serval ID
serval:BIB_63636CF05C9E
Type
Article: article from journal or magazin.
Collection
Publications
Title
Oxytocin selectively gates fear responses through distinct outputs from the central amygdala.
Journal
Science
Author(s)
Viviani D., Charlet A., van den Burg E., Robinet C., Hurni N., Abatis M., Magara F., Stoop R.
ISSN
1095-9203 (Electronic)
ISSN-L
0036-8075
Publication state
Published
Issued date
2011
Peer-reviewed
Oui
Volume
333
Number
6038
Pages
104-107
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov'tPublication Status: ppublish
Abstract
Central amygdala (CeA) projections to hypothalamic and brain stem nuclei regulate the behavioral and physiological expression of fear, but it is unknown whether these different aspects of the fear response can be separately regulated by the CeA. We combined fluorescent retrograde tracing of CeA projections to nuclei that modulate fear-related freezing or cardiovascular responses with in vitro electrophysiological recordings and with in vivo monitoring of related behavioral and physiological parameters. CeA projections emerged from separate neuronal populations with different electrophysiological characteristics and different response properties to oxytocin. In vivo, oxytocin decreased freezing responses in fear-conditioned rats without affecting the cardiovascular response. Thus, neuropeptidergic signaling can modulate the CeA outputs through separate neuronal circuits and thereby individually steer the various aspects of the fear response.
Keywords
Amygdala/physiology, Animals, Bombesin/pharmacology, Brain Stem/physiology, Conditioning (Psychology), Fear/physiology, Female, GABA-A Receptor Agonists/pharmacology, Heart Rate/drug effects, Hypothalamus/physiology, Male, Muscimol/pharmacology, Neural Inhibition, Neural Pathways/physiology, Neurons/physiology, Oxytocin/agonists, Oxytocin/analogs & derivatives, Patch-Clamp Techniques, Periaqueductal Gray/physiology, Rats, Rats, Sprague-Dawley
Pubmed
Web of science
Create date
13/07/2011 10:57
Last modification date
20/08/2019 15:20
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