Immunosuppresseurs: usages systémiques et neurologiques [Systemic and neurological uses of immunosuppressive agents].

Details

Serval ID
serval:BIB_6274D4C3C9C3
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Immunosuppresseurs: usages systémiques et neurologiques [Systemic and neurological uses of immunosuppressive agents].
Journal
Revue Médicale Suisse
Author(s)
Schnider C., Seebach J.D., Ribi C., Spertini F.
ISSN
1660-9379 (Print)
ISSN-L
1660-9379
Publication state
Published
Issued date
2013
Volume
9
Number
384
Pages
915-921
Language
french
Notes
Publication types: English Abstract ; Journal ArticlePublication Status: ppublish. PDF type: Mise au point
Abstract
Involvement of the central or peripheral nervous system, frequently present in systemic inflammatory immune disorders, has to be considered a severe threat and requires aggressive immunosuppressive treatment to achieve rapid remission. This is usually obtained with high-dose systemic corticosteroids combined with cyclophosphamide. Once remission is obtained, immunosuppressive agents with a more favorable safety profile are needed to exert a corticosteroid-sparing effect and minimize adverse events. New therapeutic approaches are currently developed to treat autoimmune diseases, mostly linked to the definition of new indications for biological agents such as TNF-alpha antagonists and rituximab.
Keywords
Antibodies, Monoclonal/therapeutic use, B-Lymphocytes/immunology, Humans, Immunosuppressive Agents/therapeutic use, Nervous System Diseases/drug therapy, Tumor Necrosis Factor-alpha/antagonists & inhibitors
Pubmed
Create date
05/08/2013 11:48
Last modification date
20/08/2019 15:19
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