Aspirin plus ticlopidine prevented experimental endocarditis due to Enterococcus faecalis and Streptococcus gallolyticus.

Details

Ressource 1Download: serval:BIB_61D89C363FF6.P001 (452.19 [Ko])
State: Public
Version: author
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It was possible to publish this article open access thanks to a Swiss National Licence with the publisher.
Serval ID
serval:BIB_61D89C363FF6
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Aspirin plus ticlopidine prevented experimental endocarditis due to Enterococcus faecalis and Streptococcus gallolyticus.
Journal
Pathogens and Disease
Author(s)
Veloso T.R., Oechslin F., Que Y.A., Moreillon P., Entenza J.M., Mancini S.
ISSN
2049-632X (Electronic)
ISSN-L
2049-632X
Publication state
Published
Issued date
2015
Volume
73
Number
8
Pages
ftv060
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Abstract
Enterococcus faecalis and Streptococcus gallolyticus cause infective endocarditis (IE), which can originate from the continuous release or translocation of low bacterial numbers into the bloodstream. In this context, IE cannot be prevented with antibiotics. We previously demonstrated that aspirin plus ticlopidine protected rats from IE due to S. gordonii and Staphylococcus aureus. Here we showed that aspirin plus ticlopidine significantly reduced vegetation weight and protected 73 and 64% rats (P < 0.005) from IE due to E. faecalis and S. gallolyticus, respectively. These results further support the potential use of aspirin plus ticlopidine for a global prevention of IE in high-risk patients.
Keywords
Animals, Aspirin/administration & dosage, Disease Models, Animal, Endocarditis, Bacterial/microbiology, Endocarditis, Bacterial/prevention & control, Enterococcus faecalis/growth & development, Female, Gram-Positive Bacterial Infections/microbiology, Gram-Positive Bacterial Infections/prevention & control, Platelet Aggregation Inhibitors/pharmacology, Rats, Wistar, Streptococcus/growth & development, Ticlopidine/administration & dosage, Treatment Outcome
Pubmed
Web of science
Open Access
Yes
Create date
09/11/2015 15:30
Last modification date
25/09/2019 7:09
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