CUBN is a gene locus for albuminuria.

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State: Public
Version: author
Serval ID
serval:BIB_61D7BB6FF101
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
CUBN is a gene locus for albuminuria.
Journal
Journal of the American Society of Nephrology
Author(s)
Böger C.A., Chen M.H., Tin A., Olden M., Köttgen A., de Boer I.H., Fuchsberger C., O'Seaghdha C.M., Pattaro C., Teumer A., Liu C.T., Glazer N.L., Li M., O'Connell J.R., Tanaka T., Peralta C.A., Kutalik Z., Luan J., Zhao J.H., Hwang S.J., Akylbekova E., Kramer H., van der Harst P., Smith A.V., Lohman K., de Andrade M., Hayward C., Kollerits B., Tönjes A., Aspelund T., Ingelsson E., Eiriksdottir G., Launer L.J., Harris T.B., Shuldiner A.R., Mitchell B.D., Arking D.E., Franceschini N., Boerwinkle E., Egan J., Hernandez D., Reilly M., Townsend R.R., Lumley T., Siscovick D.S., Psaty B.M., Kestenbaum B., Haritunians T., Bergmann S., Vollenweider P., Waeber G., Mooser V., Waterworth D., Johnson A.D., Florez J.C., Meigs J.B., Lu X., Turner S.T., Atkinson E.J., Leak T.S., Aasarød K., Skorpen F., Syvänen A.C., Illig T., Baumert J., Koenig W., Krämer B.K., Devuyst O., Mychaleckyj J.C., Minelli C., Bakker S.J., Kedenko L., Paulweber B., Coassin S., Endlich K., Kroemer H.K., Biffar R., Stracke S., Völzke H., Stumvoll M., Mägi R., Campbell H., Vitart V., Hastie N.D., Gudnason V., Kardia S.L., Liu Y., Polasek O., Curhan G., Kronenberg F., Prokopenko I., Rudan I., Arnlöv J., Hallan S., Navis G., Parsa A., Parsa A., Ferrucci L., Coresh J., Shlipak M.G., Bull S.B., Paterson N.J., Wichmann H.E., Wareham N.J., Loos R.J., Rotter J.I., Pramstaller P.P., Cupples L.A., Beckmann J.S., Yang Q., Heid I.M., Rettig R., Dreisbach A.W., Bochud M., Fox C.S., Kao W.H.
Working group(s)
CKDGen Consortium
Contributor(s)
Köttgen A., Pattaro C., Böger CA., Fuchsberger C., Olden M., Glazer NL., Parsa A., Gao X., Yang Q., Smith AV., O'Connell JR., Li M., Schmidt H., Tanaka T., Isaacs A., Ketkar S., Hwang SJ., Johnson AD., Dehghan A., Teumer A., Paré G., Aspelund T., Eiriksdottir G., Launer LJ., Harris TB., Rampersaud E., Mitchell BD., Boerwinkle E., Struchalin M., Cavalieri M., Singleton A., Giallauria F., Metter J., de Boer I., Haritunians T., Lumley T., Siscovick D., Psaty BM., Zillikens MC., Oostra BA., Feitosa M., Province M., Illig T., Klopp N., Meisinger C., Wichmann HE., Koenig W., Zgaga L., Zemunik T., Kolcic I., Minelli C., Johansson£££Åsa£££ Å. , Igl W., Zaboli G., Wild SH., Wright AF., Campbell H., Ellinghaus D., Schreiber S., Aulchenko YS., Felix JF., Rivadeneira F., Uitterlinden AG., Hofman A., Imboden M., Boban M., Campbell S., Endlich K., Völzke H., Kroemer HK., Nauck M., Völker U., Polasek O., Vitart V., Badola S., Parker AN., Ridker PM., Blankenberg S., Gudnason V., Shuldiner AR., Coresh J., Schmidt R., Ferrucci L., Shlipak MG., van Duijn CM. , Borecki I., Krämer BK., Rudan I., Gyllensten U., Wilson JF., Witteman JC., Pramstaller PP., Rettig R., Hastie ND., Chasman DI., Kao WH., Heid IM., Fox CS.
ISSN
1533-3450 (Electronic)
ISSN-L
1046-6673
Publication state
Published
Issued date
2011
Peer-reviewed
Oui
Volume
22
Number
3
Pages
555-570
Language
english
Notes
Publication types: Journal Article ; Meta-Analysis ; Research Support, N.I.H., Extramural ; Research Support, N.I.H., Intramural ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
Publication Status: ppublish
Abstract
Identification of genetic risk factors for albuminuria may alter strategies for early prevention of CKD progression, particularly among patients with diabetes. Little is known about the influence of common genetic variants on albuminuria in both general and diabetic populations. We performed a meta-analysis of data from 63,153 individuals of European ancestry with genotype information from genome-wide association studies (CKDGen Consortium) and from a large candidate gene study (CARe Consortium) to identify susceptibility loci for the quantitative trait urinary albumin-to-creatinine ratio (UACR) and the clinical diagnosis microalbuminuria. We identified an association between a missense variant (I2984V) in the CUBN gene, which encodes cubilin, and both UACR (P = 1.1 × 10(-11)) and microalbuminuria (P = 0.001). We observed similar associations among 6981 African Americans in the CARe Consortium. The associations between this variant and both UACR and microalbuminuria were significant in individuals of European ancestry regardless of diabetes status. Finally, this variant associated with a 41% increased risk for the development of persistent microalbuminuria during 20 years of follow-up among 1304 participants with type 1 diabetes in the prospective DCCT/EDIC Study. In summary, we identified a missense CUBN variant that associates with levels of albuminuria in both the general population and in individuals with diabetes.
Keywords
African Continental Ancestry Group/genetics, Albuminuria/genetics, European Continental Ancestry Group/genetics, Genetic Loci/genetics, Genetic Predisposition to Disease/genetics, Humans, Mutation, Missense/genetics, Receptors, Cell Surface/genetics
Pubmed
Web of science
Open Access
Yes
Create date
03/03/2011 8:45
Last modification date
20/08/2019 14:18
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