Premature progesterone elevation does not alter oocyte quality in in vitro fertilization
Details
Serval ID
serval:BIB_6146A1D87066
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Premature progesterone elevation does not alter oocyte quality in in vitro fertilization
Journal
Fertility and Sterility
ISSN
0015-0282
Publication state
Published
Issued date
06/1996
Peer-reviewed
Oui
Volume
65
Number
6
Pages
1178-83
Notes
Journal Article --- Old month value: Jun
Abstract
OBJECTIVE: To clarify whether premature P elevation during controlled ovarian hyperstimulation (COH) for IVF-ET affects adversely oocyte-embryo quality. DESIGN: Controlled clinical study. PATIENTS: We studied 102 fertile donors undergoing 106 oocyte retrievals and 117 recipients undergoing 162 ET. INTERVENTIONS: Donors underwent COH with a time-release GnRH agonist and hMG. All recipients had inactive or absent ovaries and were primed with E2 and P. MAIN OUTCOME MEASURES: Measurement of LH, P and E2; characteristics of COH; cleavage, pregnancy, and implantation rates. RESULTS: According to donors' plasma P levels on the day of hCG, two groups were defined: P < or = 0.9 ng/mL (conversion factor to SI unit, 3.18), group A, and P > 0.9 ng/mL, group B. Similar results of cleavage (65% and 72%), clinical (30% and 29%), and ongoing pregnancy (20% and 18%), and implantation (14% and 15%) rates were observed in both groups, respectively. CONCLUSIONS: The lack of difference in cleavage, pregnancy, and implantation rates between both groups suggests that preovulation increase in P production does not alter oocyte-embryo quality. Hence, the reported adverse effects on IVF outcome of pre-hCG elevation of P is likely to reflect an impaired endometrial receptivity in the high P group.
Keywords
Adult
Embryo Implantation
Embryo Transfer
Estradiol/blood
Female
*Fertilization in Vitro
Humans
Leuprolide/therapeutic use
Luteinizing Hormone/blood
Menotropins/therapeutic use
Oocyte Donation
Oocytes/*physiology
Ovulation Induction
Pregnancy
Progesterone/*blood
Pubmed
Web of science
Create date
28/02/2008 12:37
Last modification date
20/08/2019 15:18