Premature progesterone elevation does not alter oocyte quality in in vitro fertilization

Details

Serval ID
serval:BIB_6146A1D87066
Type
Article: article from journal or magazin.
Collection
Publications
Title
Premature progesterone elevation does not alter oocyte quality in in vitro fertilization
Journal
Fertility and Sterility
Author(s)
Fanchin  R., Righini  C., Olivennes  F., de Ziegler  D., Selva  J., Frydman  R.
ISSN
0015-0282
Publication state
Published
Issued date
06/1996
Peer-reviewed
Oui
Volume
65
Number
6
Pages
1178-83
Notes
Journal Article --- Old month value: Jun
Abstract
OBJECTIVE: To clarify whether premature P elevation during controlled ovarian hyperstimulation (COH) for IVF-ET affects adversely oocyte-embryo quality. DESIGN: Controlled clinical study. PATIENTS: We studied 102 fertile donors undergoing 106 oocyte retrievals and 117 recipients undergoing 162 ET. INTERVENTIONS: Donors underwent COH with a time-release GnRH agonist and hMG. All recipients had inactive or absent ovaries and were primed with E2 and P. MAIN OUTCOME MEASURES: Measurement of LH, P and E2; characteristics of COH; cleavage, pregnancy, and implantation rates. RESULTS: According to donors' plasma P levels on the day of hCG, two groups were defined: P < or = 0.9 ng/mL (conversion factor to SI unit, 3.18), group A, and P > 0.9 ng/mL, group B. Similar results of cleavage (65% and 72%), clinical (30% and 29%), and ongoing pregnancy (20% and 18%), and implantation (14% and 15%) rates were observed in both groups, respectively. CONCLUSIONS: The lack of difference in cleavage, pregnancy, and implantation rates between both groups suggests that preovulation increase in P production does not alter oocyte-embryo quality. Hence, the reported adverse effects on IVF outcome of pre-hCG elevation of P is likely to reflect an impaired endometrial receptivity in the high P group.
Keywords
Adult Embryo Implantation Embryo Transfer Estradiol/blood Female *Fertilization in Vitro Humans Leuprolide/therapeutic use Luteinizing Hormone/blood Menotropins/therapeutic use Oocyte Donation Oocytes/*physiology Ovulation Induction Pregnancy Progesterone/*blood
Pubmed
Web of science
Create date
28/02/2008 11:37
Last modification date
20/08/2019 14:18
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