Lung adenocarcinoma with BRAF G469L mutation refractory to vemurafenib.

Details

Serval ID
serval:BIB_6113E2F77E4E
Type
Article: article from journal or magazin.
Publication sub-type
Case report (case report): feedback on an observation with a short commentary.
Collection
Publications
Institution
Title
Lung adenocarcinoma with BRAF G469L mutation refractory to vemurafenib.
Journal
Lung Cancer
Author(s)
Gautschi O., Peters S., Zoete V., Aebersold-Keller F., Strobel K., Schwizer B., Hirschmann A., Michielin O., Diebold J.
ISSN
1872-8332 (Electronic)
ISSN-L
0169-5002
Publication state
Published
Issued date
2013
Volume
82
Number
2
Pages
365-367
Language
english
Notes
Publication types: Journal ArticlePublication Status: ppublish. pdf type: Case report
Abstract
BRAF V600E is an emerging drug target in lung cancer, but the clinical significance of non-V600 BRAF mutations in lung cancer and other malignancies is less clear. Here, we report the case of a patient with metastatic lung adenocarcinoma with BRAF G469L mutation refractory to vemurafenib. We calculated a structure model of this very rare type of mutated BRAF kinase to explain the molecular mechanism of drug resistance. This information may help to develop effective targeted therapies for cancers with non-V600 BRAF mutations.
Pubmed
Web of science
Create date
22/12/2013 17:06
Last modification date
20/08/2019 14:18
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