The emerging role of multiplex tandem mass spectrometry analysis for therapeutic drug monitoring and personalized medicine

Details

Serval ID
serval:BIB_61127FFB9A94
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
The emerging role of multiplex tandem mass spectrometry analysis for therapeutic drug monitoring and personalized medicine
Journal
TrAC Trends in Analytical Chemistry
Author(s)
Decosterd L.A., Widmer N., André P., Aouri M., Buclin T.
ISSN
0165-9936
Publication state
Published
Issued date
11/2016
Peer-reviewed
Oui
Volume
84
Pages
5-13
Language
english
Abstract
Liquid chromatography coupled to tandem mass spectrometry (LC-MS/MS) constitutes now a key instrumental component of medical laboratory centres and has greatly facilitated the development of a considerable number of drugs assays for Therapeutic Drug Monitoring (TDM). The concept of TDM implies the measurement of concentrations of certain drugs in patients' blood, followed by dosage individualization based on patients' circulating exposure, targeting a pre-defined concentration range. This approach aims at increasing the likelihood of achieving therapeutic efficacy, while reducing the risk of toxicity. TDM can contribute to the rational individualization of critical drug treatments, notably antivirals, antibiotics, antiepileptics, psychotropic drugs and targeted anticancer agents, in the context of growing efforts towards personalized medicine. This article aims at reviewing the basic concepts, the role and the perspectives of evolution of TDM. It presents selected examples of clinical applications and gives some insights on how TDM is definitely benefiting from the tremendous development of LC-MS/MS techniques.
Keywords
Analytical Chemistry, Spectroscopy, Environmental Chemistry
Create date
25/08/2016 8:55
Last modification date
20/08/2019 14:18
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