Assessment of the arterial wall and lumen with spectral computed tomography
Details
Download: thèse-RD-OK.pdf (13949.01 [Ko])
State: Public
Version: After imprimatur
License: Not specified
State: Public
Version: After imprimatur
License: Not specified
Serval ID
serval:BIB_5FB7106E2E91
Type
PhD thesis: a PhD thesis.
Collection
Publications
Institution
Title
Assessment of the arterial wall and lumen with spectral computed tomography
Director(s)
Meuli Reto
Codirector(s)
Douek Philippe, Qanadli Salah D.
Institution details
Université de Lausanne, Faculté de biologie et médecine
Publication state
Accepted
Issued date
16/12/2021
Language
english
Abstract
Computed tomography (CT) has deeply affected the approach to diagnosis in medical practice and is heavily relied on for numerous therapeutic decisions. Meanwhile, diagnostic imaging and CT in particular remains at the core of medical innovation, not least due to remarkable developments on the imaging chain. After three decades of conventional CT – intrinsically disregarding energy-dependency of X-ray attenuation – spectral CT became available clinically, fostering research and improvement of patient management. Spectral CT is regarded as a disruptive technology that can affect workflow, patient safety, and diagnostic accuracy but needs validation. With this in mind, we sought to explore the potential benefits of spectral CT for evaluating cardiovascular disease.
To provide a thorough assessment of spectral CT in evaluating vascular lumen and wall, we designed several phantom experiments to assess the feasibility of dedicated tasks and expanded our research to clinical studies for validation. To this end, we used both clinically available dual-energy CT (DECT) and pre-clinical multi-energy (spectral photon-counting detector CT [SPCCT]) platforms.
We confirmed that DECT can save radiation dose thanks to virtual non-contrast reconstructions, reduce iodine doses considerably for coronary artery imaging, and task-oriented material decomposition reconstructions improve aortic wall conspicuity, notably in aortic intramural hematoma. We also showed that SPCCT coronary angiography outperforms DECT in terms of noise, spatial resolution, and diagnostic performance. These findings advance both patient safety and the clinical value of spectral CT in cardiovascular imaging.
To provide a thorough assessment of spectral CT in evaluating vascular lumen and wall, we designed several phantom experiments to assess the feasibility of dedicated tasks and expanded our research to clinical studies for validation. To this end, we used both clinically available dual-energy CT (DECT) and pre-clinical multi-energy (spectral photon-counting detector CT [SPCCT]) platforms.
We confirmed that DECT can save radiation dose thanks to virtual non-contrast reconstructions, reduce iodine doses considerably for coronary artery imaging, and task-oriented material decomposition reconstructions improve aortic wall conspicuity, notably in aortic intramural hematoma. We also showed that SPCCT coronary angiography outperforms DECT in terms of noise, spatial resolution, and diagnostic performance. These findings advance both patient safety and the clinical value of spectral CT in cardiovascular imaging.
Keywords
medical imaging, computed tomography, cardiovascular radiology, photon counting detector, spectral
Create date
16/12/2021 12:55
Last modification date
01/09/2023 6:27