Hepatitis C virus infection after liver transplantation is associated with lower levels of activated CD4(+)CD25(+)CD45RO(+)IL-7ralpha(high) T cells.

Details

Serval ID
serval:BIB_5D74E00D85A8
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Hepatitis C virus infection after liver transplantation is associated with lower levels of activated CD4(+)CD25(+)CD45RO(+)IL-7ralpha(high) T cells.
Journal
Liver Transplantation : Official Publication of the American Association For the Study of Liver Diseases and the International Liver Transplantation Society
Author(s)
Ciuffreda D., Codarri L., Buhler L., Vallotton L., Giostra E., Mentha G., Morel P., Pantaleo G., Pascual M.
ISSN
1527-6473[electronic], 1527-6465[linking]
Publication state
Published
Issued date
2010
Volume
16
Number
1
Pages
49-55
Language
english
Notes
Publication types: Journal Article
Publication Status: ppublish
Abstract
The expression of interleukin 7 receptor alpha(high) (IL-7Ralpha(high)) discriminates between activated CD25(+)CD45RO(+)CD4(+) T cells [IL-7Ralpha(high) and forkhead box P3-negative (FoxP3(-))] and regulatory T cells (IL-7Ralpha(low) and FoxP3(+)). The IL-7Ralpha(high)CD25(+)CD45RO(+)CD4(+)FoxP3(-) T cell population has been shown to be expanded in the blood and tissues of patients after kidney transplantation and to contain alloreactive T cells (activated T cells). In the present study, we analyzed the distribution of IL-7Ralpha(high)CD25(+)CD45RO(+)CD4(+)FoxP3(-) T cells in the blood of 53 patients after liver transplantation. The IL-7Ralpha(high)CD25(+)CD45RO(+)CD4(+)FoxP3(-) T cell population was significantly expanded (P < 0.0001) in stable transplant recipients versus healthy donors. However, the magnitude of the expansion was significantly higher (P < 0.0001) in liver transplant recipients with no hepatitis C virus (HCV) infection in comparison with those with a preexisting HCV infection. Interestingly, effective suppression of HCV viremia after antiviral therapy was associated with an increase in the IL-7Ralpha(high)CD25(+)CD45RO(+)CD4(+)FoxP3(-) T cell population to levels comparable to those of liver transplant recipients not infected with HCV. The present results indicate that (1) the IL-7Ralpha(high)CD25(+)CD45RO(+)CD4(+)FoxP3(-) T cell population is expanded after liver transplantation, (2) it is a valuable immunological marker for monitoring activated and potential alloreactive CD4 T cells in liver transplantation, and (3) a preexisting HCV infection negatively influences the expansion of this population in liver transplant recipients.
Keywords
Adult, Aged, Antiviral Agents/therapeutic use, Case-Control Studies, Down-Regulation, Female, Hepatitis C, Chronic/drug therapy, Hepatitis C, Chronic/immunology, Humans, Interleukin-7 Receptor alpha Subunit/metabolism, Liver Transplantation, Male, Middle Aged, Postoperative Complications/immunology, T-Lymphocytes, Regulatory/metabolism, Young Adult
Pubmed
Web of science
Open Access
Yes
Create date
26/01/2010 16:21
Last modification date
20/08/2019 15:15
Usage data