Hepatitis C virus infection after liver transplantation is associated with lower levels of activated CD4(+)CD25(+)CD45RO(+)IL-7ralpha(high) T cells.
Details
Serval ID
serval:BIB_5D74E00D85A8
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Hepatitis C virus infection after liver transplantation is associated with lower levels of activated CD4(+)CD25(+)CD45RO(+)IL-7ralpha(high) T cells.
Journal
Liver Transplantation : Official Publication of the American Association For the Study of Liver Diseases and the International Liver Transplantation Society
ISSN
1527-6473[electronic], 1527-6465[linking]
Publication state
Published
Issued date
2010
Volume
16
Number
1
Pages
49-55
Language
english
Notes
Publication types: Journal Article
Publication Status: ppublish
Publication Status: ppublish
Abstract
The expression of interleukin 7 receptor alpha(high) (IL-7Ralpha(high)) discriminates between activated CD25(+)CD45RO(+)CD4(+) T cells [IL-7Ralpha(high) and forkhead box P3-negative (FoxP3(-))] and regulatory T cells (IL-7Ralpha(low) and FoxP3(+)). The IL-7Ralpha(high)CD25(+)CD45RO(+)CD4(+)FoxP3(-) T cell population has been shown to be expanded in the blood and tissues of patients after kidney transplantation and to contain alloreactive T cells (activated T cells). In the present study, we analyzed the distribution of IL-7Ralpha(high)CD25(+)CD45RO(+)CD4(+)FoxP3(-) T cells in the blood of 53 patients after liver transplantation. The IL-7Ralpha(high)CD25(+)CD45RO(+)CD4(+)FoxP3(-) T cell population was significantly expanded (P < 0.0001) in stable transplant recipients versus healthy donors. However, the magnitude of the expansion was significantly higher (P < 0.0001) in liver transplant recipients with no hepatitis C virus (HCV) infection in comparison with those with a preexisting HCV infection. Interestingly, effective suppression of HCV viremia after antiviral therapy was associated with an increase in the IL-7Ralpha(high)CD25(+)CD45RO(+)CD4(+)FoxP3(-) T cell population to levels comparable to those of liver transplant recipients not infected with HCV. The present results indicate that (1) the IL-7Ralpha(high)CD25(+)CD45RO(+)CD4(+)FoxP3(-) T cell population is expanded after liver transplantation, (2) it is a valuable immunological marker for monitoring activated and potential alloreactive CD4 T cells in liver transplantation, and (3) a preexisting HCV infection negatively influences the expansion of this population in liver transplant recipients.
Keywords
Adult, Aged, Antiviral Agents/therapeutic use, Case-Control Studies, Down-Regulation, Female, Hepatitis C, Chronic/drug therapy, Hepatitis C, Chronic/immunology, Humans, Interleukin-7 Receptor alpha Subunit/metabolism, Liver Transplantation, Male, Middle Aged, Postoperative Complications/immunology, T-Lymphocytes, Regulatory/metabolism, Young Adult
Pubmed
Web of science
Open Access
Yes
Create date
26/01/2010 16:21
Last modification date
20/08/2019 15:15