Meta-analyses identify DNA methylation associated with kidney function and damage.

Details

Serval ID
serval:BIB_5CB7B327B481
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Meta-analyses identify DNA methylation associated with kidney function and damage.
Journal
Nature communications
Author(s)
Schlosser P., Tin A., Matias-Garcia P.R., Thio CHL, Joehanes R., Liu H., Weihs A., Yu Z., Hoppmann A., Grundner-Culemann F., Min J.L., Adeyemo A.A., Agyemang C., Ärnlöv J., Aziz N.A., Baccarelli A., Bochud M., Brenner H., Breteler MMB, Carmeli C., Chaker L., Chambers J.C., Cole S.A., Coresh J., Corre T., Correa A., Cox S.R., de Klein N., Delgado G.E., Domingo-Relloso A., Eckardt K.U., Ekici A.B., Endlich K., Evans K.L., Floyd J.S., Fornage M., Franke L., Fraszczyk E., Gao X., Gào X., Ghanbari M., Ghasemi S., Gieger C., Greenland P., Grove M.L., Harris S.E., Hemani G., Henneman P., Herder C., Horvath S., Hou L., Hurme M.A., Hwang S.J., Jarvelin M.R., Kardia SLR, Kasela S., Kleber M.E., Koenig W., Kooner J.S., Kramer H., Kronenberg F., Kühnel B., Lehtimäki T., Lind L., Liu D., Liu Y., Lloyd-Jones D.M., Lohman K., Lorkowski S., Lu A.T., Marioni R.E., März W., McCartney D.L., Meeks KAC, Milani L., Mishra P.P., Nauck M., Navas-Acien A., Nowak C., Peters A., Prokisch H., Psaty B.M., Raitakari O.T., Ratliff S.M., Reiner A.P., Rosas S.E., Schöttker B., Schwartz J., Sedaghat S., Smith J.A., Sotoodehnia N., Stocker H.R., Stringhini S., Sundström J., Swenson B.R., Tellez-Plaza M., van Meurs JBJ, van Vliet-Ostaptchouk J.V., Venema A., Verweij N., Walker R.M., Wielscher M., Winkelmann J., Wolffenbuttel BHR, Zhao W., Zheng Y., Loh M., Snieder H., Levy D., Waldenberger M., Susztak K., Köttgen A., Teumer A.
Working group(s)
Estonian Biobank Research Team, Genetics of DNA Methylation Consortium
Contributor(s)
Milani L.
ISSN
2041-1723 (Electronic)
ISSN-L
2041-1723
Publication state
Published
Issued date
09/12/2021
Peer-reviewed
Oui
Volume
12
Number
1
Pages
7174
Language
english
Notes
Publication types: Journal Article
Publication Status: epublish
Abstract
Chronic kidney disease is a major public health burden. Elevated urinary albumin-to-creatinine ratio is a measure of kidney damage, and used to diagnose and stage chronic kidney disease. To extend the knowledge on regulatory mechanisms related to kidney function and disease, we conducted a blood-based epigenome-wide association study for estimated glomerular filtration rate (n = 33,605) and urinary albumin-to-creatinine ratio (n = 15,068) and detected 69 and seven CpG sites where DNA methylation was associated with the respective trait. The majority of these findings showed directionally consistent associations with the respective clinical outcomes chronic kidney disease and moderately increased albuminuria. Associations of DNA methylation with kidney function, such as CpGs at JAZF1, PELI1 and CHD2 were validated in kidney tissue. Methylation at PHRF1, LDB2, CSRNP1 and IRF5 indicated causal effects on kidney function. Enrichment analyses revealed pathways related to hemostasis and blood cell migration for estimated glomerular filtration rate, and immune cell activation and response for urinary albumin-to-creatinineratio-associated CpGs.
Pubmed
Web of science
Open Access
Yes
Create date
20/12/2021 14:36
Last modification date
22/04/2022 6:37
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