Timing is everything: dendritic cell subsets in murine Leishmania infection.

Details

Serval ID
serval:BIB_5CA89D6B9998
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Timing is everything: dendritic cell subsets in murine Leishmania infection.
Journal
Trends in Parasitology
Author(s)
Ashok D., Acha-Orbea H.
ISSN
1471-5007 (Electronic)
ISSN-L
1471-4922
Publication state
Published
Issued date
2014
Volume
30
Number
10
Pages
499-507
Language
english
Abstract
Mouse models of Leishmania major infection have shown that a predominant CD4(+) T helper type 1 cell (Th1) response leads to protection, while T helper type 2 cell (Th2) predominance confers susceptibility. Dendritic cells (DCs) are antigen-presenting cells that orchestrate the T cell response. The immune response to L. major involves direct antigen presentation by migrating DCs or transfer of antigens to resident DCs to prime T cells. In this review, we discuss the timing and consequences of antigen presentation by DC subsets and how this affects Leishmania susceptibility. We propose a model where dermal DCs and Langerhans cells play a role early in infection, followed by inflammatory monocyte-derived DC and lymph node (LN)-resident DCs at later time points of infection to establish the resistant Th1 response.
Keywords
Animals, Antigen Presentation/immunology, Dendritic Cells/immunology, Leishmania/immunology, Leishmaniasis/immunology, Mice, Th1 Cells/immunology
Pubmed
Web of science
Create date
20/11/2014 11:35
Last modification date
20/08/2019 15:15
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