Transdermal clonidine therapy in hypertensive patients. Effects on office and ambulatory recorded blood pressure values

Details

Serval ID
serval:BIB_5C8421EFB370
Type
Article: article from journal or magazin.
Collection
Publications
Title
Transdermal clonidine therapy in hypertensive patients. Effects on office and ambulatory recorded blood pressure values
Journal
JAMA
Author(s)
Schaller  M. D., Nussberger  J., Waeber  B., Porchet  M., Brunner  H. R.
ISSN
0098-7484 (Print)
Publication state
Published
Issued date
01/1985
Volume
253
Number
2
Pages
233-5
Notes
Journal Article
Research Support, Non-U.S. Gov't --- Old month value: Jan 11
Abstract
The antihypertensive effect of clonidine hydrochloride delivered at a constant rate for seven days by transdermal disks was evaluated in seven patients with essential hypertension. Blood pressure values measured at the physician's office were not significantly decreased by one month of treatment with one (n = 2) or two (n = 5) once-weekly applied clonidine transdermal disks. In contrast, blood pressure values recorded during patients' customary daily activities by means of a portable blood pressure recorder were considerably reduced, from 159/97 +/- 2/2 to 136/76 +/- 7/5 mm Hg. Plasma drug concentration at the end of the fourth week averaged 1.22 +/- 0.24 ng/mL. Plasma renin, vasopressin, and epinephrine levels were not modified by clonidine, whereas plasma norepinephrine level was significantly reduced. Local skin erythema developed in three patients and dry mouth in six. These findings suggest that clonidine transdermal disks lower blood pressure in hypertensive patients, but produce local skin lesions and general side effects.
Keywords
Administration, Topical Adult Blood Pressure/drug effects Blood Pressure Determination/methods Clonidine/*administration & dosage/adverse effects Female Heart Rate/drug effects Humans Hypertension/blood/*drug therapy/physiopathology Male Middle Aged Monitoring, Physiologic
Pubmed
Web of science
Create date
05/03/2008 16:39
Last modification date
20/08/2019 14:15
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