Transdermal clonidine therapy in hypertensive patients. Effects on office and ambulatory recorded blood pressure values

Détails

ID Serval
serval:BIB_5C8421EFB370
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Transdermal clonidine therapy in hypertensive patients. Effects on office and ambulatory recorded blood pressure values
Périodique
JAMA
Auteur(s)
Schaller  M. D., Nussberger  J., Waeber  B., Porchet  M., Brunner  H. R.
ISSN
0098-7484 (Print)
Statut éditorial
Publié
Date de publication
01/1985
Volume
253
Numéro
2
Pages
233-5
Notes
Journal Article
Research Support, Non-U.S. Gov't --- Old month value: Jan 11
Résumé
The antihypertensive effect of clonidine hydrochloride delivered at a constant rate for seven days by transdermal disks was evaluated in seven patients with essential hypertension. Blood pressure values measured at the physician's office were not significantly decreased by one month of treatment with one (n = 2) or two (n = 5) once-weekly applied clonidine transdermal disks. In contrast, blood pressure values recorded during patients' customary daily activities by means of a portable blood pressure recorder were considerably reduced, from 159/97 +/- 2/2 to 136/76 +/- 7/5 mm Hg. Plasma drug concentration at the end of the fourth week averaged 1.22 +/- 0.24 ng/mL. Plasma renin, vasopressin, and epinephrine levels were not modified by clonidine, whereas plasma norepinephrine level was significantly reduced. Local skin erythema developed in three patients and dry mouth in six. These findings suggest that clonidine transdermal disks lower blood pressure in hypertensive patients, but produce local skin lesions and general side effects.
Mots-clé
Administration, Topical Adult Blood Pressure/drug effects Blood Pressure Determination/methods Clonidine/*administration & dosage/adverse effects Female Heart Rate/drug effects Humans Hypertension/blood/*drug therapy/physiopathology Male Middle Aged Monitoring, Physiologic
Pubmed
Web of science
Création de la notice
05/03/2008 16:39
Dernière modification de la notice
20/08/2019 14:15
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