Offspring of diabetic pregnancy: long-term outcomes.

Details

Serval ID
serval:BIB_5B6C4C4D81AB
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Title
Offspring of diabetic pregnancy: long-term outcomes.
Journal
Seminars in Fetal and Neonatal Medicine
Author(s)
Simeoni U., Barker D.J.
ISSN
1744-165X (Print)
ISSN-L
1744-165X
Publication state
Published
Issued date
2009
Peer-reviewed
Oui
Volume
14
Number
2
Pages
119-124
Language
english
Notes
Publication types: Journal Article ; Review Publication Status: ppublish
Abstract
Diabetes in pregnancy has been shown to induce long-term effects in offspring. While considerable attention is focused on the increased incidence of type 2 diabetes mellitus (T2DM) in adult offspring from diabetic mothers, cardiovascular alterations, including hypertension, are also part of lifelong consequences of in-utero exposure to increased glucose concentrations. This review examines the epidemiologic and mechanistic issues involved in the developmental programming of long-term consequences in offspring of diabetic mothers, with a particular emphasis on the renal and vascular mechanisms of hypertension. The factors of increased incidence of T2DM and of obesity in adults born after exposure to diabetes during pregnancy are also discussed, as evidence is accumulating that a vicious circle involving lifelong consequences of diabetes in pregnancy in offspring contributes to the current worldwide epidemic of T2DM.
Keywords
Adolescent, Adult, Child, Child, Preschool, Diabetes Mellitus, Type 2/etiology, Female, Humans, Hyperglycemia/complications, Hypertension/etiology, Insulin Resistance, Obesity/etiology, Pregnancy, Pregnancy in Diabetics, Prenatal Exposure Delayed Effects, Young Adult
Pubmed
Web of science
Create date
22/02/2015 10:55
Last modification date
20/08/2019 14:14
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