Circulating endogenous opioids and ventilatory response to CO2 and hypoxia
Details
Serval ID
serval:BIB_5B15E65AF745
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Circulating endogenous opioids and ventilatory response to CO2 and hypoxia
Journal
Respiration Physiology
ISSN
0034-5687 (Print)
Publication state
Published
Issued date
07/1985
Volume
61
Number
1
Pages
85-93
Notes
Journal Article --- Old month value: Jul
Abstract
The role of endogenous opioids in the control of breathing is not yet well defined. Radioimmunoassays that measure beta-endorphin (BE) and met-enkephalin (MET) having recently become available, we decided to evaluate the possible relation between the blood levels of these two opioids and different hypercapnic and hypoxic ventilatory responses observed in a group of normal subjects. Ventilatory response to hypercapnia (n = 9) and to hypoxia (n = 7) were determined by classical rebreathing methods. A voluntary isocapnic normoxic hyperventilation test was used as a control. Basal levels of BE and MET did not correlate with the magnitude of the ventilatory response to either hypercapnia or hypoxia. Moreover, BE and MET levels measured repeatedly up to 30 min after each test did not change significantly. We conclude that circulating endogenous opioids do not play a role in the control of breathing in normal humans. These results do not rule out a possible role for these substances as locally released mediators.
Keywords
Adult
Anoxia/blood/*physiopathology
Carbon Dioxide/*pharmacology
Endorphins/*blood
Enkephalin, Methionine/*blood
Female
Humans
Hydrocortisone/blood
Hypercapnia/blood/physiopathology
Male
Respiration/*drug effects
beta-Endorphin
Pubmed
Web of science
Create date
15/02/2008 17:57
Last modification date
20/08/2019 15:14