Circulating endogenous opioids and ventilatory response to CO2 and hypoxia

Détails

ID Serval
serval:BIB_5B15E65AF745
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Circulating endogenous opioids and ventilatory response to CO2 and hypoxia
Périodique
Respiration Physiology
Auteur(s)
Rochat  T., Junod  A. F., Gaillard  R. C.
ISSN
0034-5687 (Print)
Statut éditorial
Publié
Date de publication
07/1985
Volume
61
Numéro
1
Pages
85-93
Notes
Journal Article --- Old month value: Jul
Résumé
The role of endogenous opioids in the control of breathing is not yet well defined. Radioimmunoassays that measure beta-endorphin (BE) and met-enkephalin (MET) having recently become available, we decided to evaluate the possible relation between the blood levels of these two opioids and different hypercapnic and hypoxic ventilatory responses observed in a group of normal subjects. Ventilatory response to hypercapnia (n = 9) and to hypoxia (n = 7) were determined by classical rebreathing methods. A voluntary isocapnic normoxic hyperventilation test was used as a control. Basal levels of BE and MET did not correlate with the magnitude of the ventilatory response to either hypercapnia or hypoxia. Moreover, BE and MET levels measured repeatedly up to 30 min after each test did not change significantly. We conclude that circulating endogenous opioids do not play a role in the control of breathing in normal humans. These results do not rule out a possible role for these substances as locally released mediators.
Mots-clé
Adult Anoxia/blood/*physiopathology Carbon Dioxide/*pharmacology Endorphins/*blood Enkephalin, Methionine/*blood Female Humans Hydrocortisone/blood Hypercapnia/blood/physiopathology Male Respiration/*drug effects beta-Endorphin
Pubmed
Web of science
Création de la notice
15/02/2008 17:57
Dernière modification de la notice
20/08/2019 15:14
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