Shaping chromosomes by DNA capture and release: gating the SMC rings.

Details

Serval ID
serval:BIB_5B0C94116F35
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Title
Shaping chromosomes by DNA capture and release: gating the SMC rings.
Journal
Current opinion in cell biology
Author(s)
Gruber S.
ISSN
1879-0410 (Electronic)
ISSN-L
0955-0674
Publication state
Published
Issued date
06/2017
Peer-reviewed
Oui
Volume
46
Pages
87-93
Language
english
Notes
Publication types: Journal Article ; Review
Publication Status: ppublish
Abstract
SMC proteins organize chromosomes to coordinate essential nuclear processes such as gene expression and DNA recombination as well as to segregate chromosomes during cell division. SMC mediated DNA bridging keeps sister chromatids aligned for much of the cell cycle, while the active extrusion of DNA loops by SMC presumably compacts chromosomes. Chromosome superstructure is thus given by the number of DNA linkages and the size of chromosomal DNA loops, which in turn depend on the dynamics of SMC loading and unloading. The latter is regulated by the intrinsic SMC ATPase activity, multiple external factors and post-translational modification. Here, I highlight recent advances in our understanding of DNA capture and release by SMC-with a focus on cohesin.

Keywords
Adenosine Triphosphatases/metabolism, Animals, Cell Cycle Proteins/metabolism, Cell Division, Chromatids/metabolism, Chromosomal Proteins, Non-Histone/metabolism, Chromosomes/metabolism, DNA/metabolism, DNA-Binding Proteins/metabolism, Humans, Multiprotein Complexes/metabolism, Protein Processing, Post-Translational, Yeasts/metabolism
Pubmed
Web of science
Create date
02/05/2017 17:30
Last modification date
20/08/2019 15:14
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