Shaping chromosomes by DNA capture and release: gating the SMC rings.

Détails

ID Serval
serval:BIB_5B0C94116F35
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Institution
Titre
Shaping chromosomes by DNA capture and release: gating the SMC rings.
Périodique
Current opinion in cell biology
Auteur(s)
Gruber S.
ISSN
1879-0410 (Electronic)
ISSN-L
0955-0674
Statut éditorial
Publié
Date de publication
06/2017
Peer-reviewed
Oui
Volume
46
Pages
87-93
Langue
anglais
Notes
Publication types: Journal Article ; Review
Publication Status: ppublish
Résumé
SMC proteins organize chromosomes to coordinate essential nuclear processes such as gene expression and DNA recombination as well as to segregate chromosomes during cell division. SMC mediated DNA bridging keeps sister chromatids aligned for much of the cell cycle, while the active extrusion of DNA loops by SMC presumably compacts chromosomes. Chromosome superstructure is thus given by the number of DNA linkages and the size of chromosomal DNA loops, which in turn depend on the dynamics of SMC loading and unloading. The latter is regulated by the intrinsic SMC ATPase activity, multiple external factors and post-translational modification. Here, I highlight recent advances in our understanding of DNA capture and release by SMC-with a focus on cohesin.

Mots-clé
Adenosine Triphosphatases/metabolism, Animals, Cell Cycle Proteins/metabolism, Cell Division, Chromatids/metabolism, Chromosomal Proteins, Non-Histone/metabolism, Chromosomes/metabolism, DNA/metabolism, DNA-Binding Proteins/metabolism, Humans, Multiprotein Complexes/metabolism, Protein Processing, Post-Translational, Yeasts/metabolism
Pubmed
Web of science
Création de la notice
02/05/2017 16:30
Dernière modification de la notice
20/08/2019 14:14
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