Bgee: integrating and comparing heterogeneous transcriptome data among species

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State: Serval
Version: author
Serval ID
serval:BIB_5A6F9D63F92D
Type
Inproceedings: an article in a conference proceedings.
Collection
Publications
Title
Bgee: integrating and comparing heterogeneous transcriptome data among species
Title of the conference
Data Integration in Life Sciences
Author(s)
Bastian F., Parmentier G., Roux J., Moretti S., Laudet V., Robinson-Rechavi M.
Publisher
Springer
Address
Berlin
ISBN
0302-9743
Publication state
Published
Issued date
2008
Peer-reviewed
Oui
Editor
Istrail S., Pevzner P., Waterman M.
Volume
5109
Series
Lecture Notes in Computer Science
Pages
124-131
Language
english
Notes
5th International Workshop, DILS 2008, Evry, France, June 25-27, 2008. Proceedings
Abstract
Gene expression patterns are a key feature in understanding gene function, notably in development. Comparing gene expression patterns between animals is a major step in the study of gene function as well as of animal evolution. It also provides a link between genes and phenotypes. Thus we have developed Bgee, a database designed to compare expression patterns between animals, by implementing ontologies describing anatomies and developmental stages of species, and then designing homology relationships between anatomies and comparison criteria between developmental stages. To define homology relationships between anatomical features we have developed the software Homolonto, which uses a modified ontology alignment approach to propose homology relationships between ontologies. Bgee then uses these aligned ontologies, onto which heterogeneous expression data types are mapped. These already include microarrays and ESTs.
Keywords
gene expression pattern, homology, ontology, data integration
Open Access
Yes
Create date
21/04/2008 14:21
Last modification date
08/05/2019 19:02
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