Jonctions communicantes et pathologies. [Gap functions and diseases]

Details

Serval ID
serval:BIB_595104D461EF
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Title
Jonctions communicantes et pathologies. [Gap functions and diseases]
Journal
Revue Médicale Suisse
Author(s)
Allagnat  F., Krattinger  N., Nicod  P., Meda  P., Haefliger  J. A.
ISSN
1660-9379 (Print)
Publication state
Published
Issued date
04/2005
Volume
1
Number
17
Pages
1126-30, 1132-3
Notes
English Abstract
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.
Review --- Old month value: Apr 27
Abstract
Gap junctions are highly conserved structures that provide cells with a direct pathway for sharing ions, nutrients and other intracellular messengers, thus participating to the homeostasis of various tissues. Research on transgenic mice has revealed a major involvement of gap junctions proteins (connexins) in several cellular functions. At the same time, an increasing number of mutations of connexin genes has been linked to several hereditary diseases, including peripheral neuropathies, skin diseases, genetic deafness, cataracts and some forms of epilepsy. This review summarizes the state of knowledge about the implication of connexins in human pathologies.
Keywords
Connexins/*physiology Disease/*etiology Gap Junctions/*physiology Humans
Pubmed
Create date
25/01/2008 14:48
Last modification date
20/08/2019 15:12
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