Practice-induced functional plasticity in inhibitory control interacts with aging.

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Serval ID
serval:BIB_57625D2C0256
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Practice-induced functional plasticity in inhibitory control interacts with aging.
Journal
Brain and cognition
Author(s)
Hartmann L., Wachtl L., de Lucia M., Spierer L.
ISSN
1090-2147 (Electronic)
ISSN-L
0278-2626
Publication state
Published
Issued date
06/2019
Peer-reviewed
Oui
Volume
132
Pages
22-32
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Abstract
Inhibitory control deficits represent a key aspect of the cognitive declines associated with aging. Practicing inhibitory control has thus been advanced as a potential approach to compensate for age-induced neurocognitive impairments. Yet, the functional brain changes associated with practicing inhibitory control tasks in older adults and whether they differ from those observed in young populations remains unresolved. We compared electrical neuroimaging analyses of ERPs recorded during a Go/NoGo practice session with a Group (Young; Older adults) by Session (Beginning; End of the practice) design to identify whether the practice of an inhibition task in older adults reinforces already implemented compensatory activity or reduce it by enhancing the functioning of the brain networks primarily involved in the tasks. We observed an equivalent small effect of practice on performance in the two age-groups. The topographic ERP analyses and source estimations revealed qualitatively different effects of the practice over the N2 and P3 ERP components, respectively driven by a decrease in supplementary motor area activity and an increase in left ventrolateral prefrontal activity in the older but not in the young adults with practice. Our results thus indicate that inhibition task practice in older adults increases age-related divergences in the underlying functional processes.
Keywords
Adult, Aged, Aging/physiology, Brain/physiology, Cerebral Cortex/physiology, Electroencephalography/methods, Event-Related Potentials, P300/physiology, Evoked Potentials/physiology, Humans, Inhibition (Psychology), Male, Middle Aged, Motor Cortex/physiology, Neuroimaging, Neuronal Plasticity, Practice (Psychology), Prefrontal Cortex/physiology, Reaction Time/physiology, Young Adult, Aging, ERP, Inhibitory control, Plasticity, Source estimations, Topography
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Web of science
Create date
23/03/2019 15:24
Last modification date
18/09/2019 6:10
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