Xenotransplantation: back to the future?

Details

Serval ID
serval:BIB_571A0830C12B
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Xenotransplantation: back to the future?
Journal
Transplant international
Author(s)
Meier RPH, Muller Y.D., Balaphas A., Morel P., Pascual M., Seebach J.D., Buhler L.H.
ISSN
1432-2277 (Electronic)
ISSN-L
0934-0874
Publication state
Published
Issued date
05/2018
Peer-reviewed
Oui
Volume
31
Number
5
Pages
465-477
Language
english
Notes
Publication types: Journal Article ; Review
Publication Status: ppublish
Abstract
The field of xenotransplantation has fluctuated between great optimism and doubts over the last 50 years. The initial clinical attempts were extremely ambitious but faced technical and ethical issues that prompted the research community to go back to preclinical studies. Important players left the field due to perceived xenozoonotic risks and the lack of progress in pig-to-nonhuman-primate transplant models. Initial apparently unsurmountable issues appear now to be possible to overcome due to progress of genetic engineering, allowing the generation of multiple-xenoantigen knockout pigs that express human transgenes and the genomewide inactivation of porcine endogenous retroviruses. These important steps forward were made possible by new genome editing technologies, such as CRISPR/Cas9, allowing researchers to precisely remove or insert genes anywhere in the genome. An additional emerging perspective is the possibility of growing humanized organs in pigs using blastocyst complementation. This article summarizes the current advances in xenotransplantation research in nonhuman primates, and it describes the newly developed genome editing technology tools and interspecific organ generation.
Keywords
Animals, Animals, Genetically Modified, Gene Editing, Graft Rejection/etiology, Humans, Primates, Swine, Transplantation Chimera, Transplantation, Heterologous/adverse effects, CRISPR Cas/9, TALEN, blastocyst complementation, cell transplantation, genome editing technologies, interspecific organ generation, nonhuman primates, nucleases, safety, transplantation, xenotransplantation, xenozoonosis
Pubmed
Web of science
Create date
07/12/2017 18:53
Last modification date
20/08/2019 15:11
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