gcodeml: A Grid-enabled Tool for Detecting Positive Selection in Biological Evolution

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State: Serval
Version: author
Serval ID
serval:BIB_542C5BE6E2B7
Type
A part of a book
Collection
Publications
Title
gcodeml: A Grid-enabled Tool for Detecting Positive Selection in Biological Evolution
Title of the book
HealthGrid Applications and Technologies Meet Science Gateways for Life Sciences
Author(s)
Moretti S., Murri R., Maffioletti S., Kuzniar A., Castella B, Salamin N., Robinson-Rechavi M., Stockinger H.
Publisher
IOS Press Books online
ISBN
978-1-61499-053-6
Publication state
Published
Issued date
2012
Editor
Glatard T, Silverstein J
Volume
175
Series
Studies in Health Technology and Informatics
Pages
59-68
Language
english
Notes
ArXiv: http://arxiv.org/abs/1203.309 pas encore index; dans PubMed
Abstract
One of the important questions in biological evolution is to know if certain changes along protein coding genes have contributed to the adaptation of species. This problem is known to be biologically complex and computationally very expensive. It, therefore, requires efficient Grid or cluster solutions to overcome the computational challenge. We have developed a Grid-enabled tool (gcodeml) that relies on the PAML (codeml) package to help analyse large phylogenetic datasets on both Grids and computational clusters. Although we report on results for gcodeml, our approach is applicable and customisable to related problems in biology or other scientific domains.
Create date
27/02/2012 10:44
Last modification date
03/03/2018 17:17
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