Zymosan induced arthritis in mice is biphasic and acts through the TLR2 pathway

Details

Serval ID
serval:BIB_53E9EC156ED1
Type
Inproceedings: an article in a conference proceedings.
Publication sub-type
Abstract (Abstract): shot summary in a article that contain essentials elements presented during a scientific conference, lecture or from a poster.
Collection
Publications
Institution
Title
Zymosan induced arthritis in mice is biphasic and acts through the TLR2 pathway
Title of the conference
EULAR 2003, Annual European Congress of Rheumatology
Author(s)
Le Roy D., So A., Busso N., Tarussio D., Chobaz V.
Address
Lisbon, Portugal, June 18-21, 2003
ISBN
0003-4967
Publication state
Published
Issued date
2003
Peer-reviewed
Oui
Volume
62
Series
Annals of the Rheumatic Diseases
Pages
138
Language
english
Abstract
Zymosan induced arthritis is thought to be dependent on activation of the alternative pathway of complement and is short lived. Recently it has been demonstrated that zymosan is capable of activating the innate immune system via toll-like receptor 2 (TLR2) and TLR6. These receptors play a role in linking the innate to the adaptive immune response. We have therefore reinvestigated the mechanisms by which zymosan induces arthritis by analyzing the kinetic of inflammation, the joint histology, lymphocyte proliferation in wild type and TLR2 deficient mice.
Web of science
Create date
23/02/2011 12:20
Last modification date
20/08/2019 14:08
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