MRI-Compatible and Conformal Electrocorticography Grids for Translational Research.

Details

Serval ID
serval:BIB_53CDCE390C81
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
MRI-Compatible and Conformal Electrocorticography Grids for Translational Research.
Journal
Advanced science
Author(s)
Fallegger F., Schiavone G., Pirondini E., Wagner F.B., Vachicouras N., Serex L., Zegarek G., May A., Constanthin P., Palma M., Khoshnevis M., Van Roost D., Yvert B., Courtine G., Schaller K., Bloch J., Lacour S.P.
ISSN
2198-3844 (Electronic)
ISSN-L
2198-3844
Publication state
Published
Issued date
05/2021
Peer-reviewed
Oui
Volume
8
Number
9
Pages
2003761
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: epublish
Abstract
Intraoperative electrocorticography (ECoG) captures neural information from the surface of the cerebral cortex during surgeries such as resections for intractable epilepsy and tumors. Current clinical ECoG grids come in evenly spaced, millimeter-sized electrodes embedded in silicone rubber. Their mechanical rigidity and fixed electrode spatial resolution are common shortcomings reported by the surgical teams. Here, advances in soft neurotechnology are leveraged to manufacture conformable subdural, thin-film ECoG grids, and evaluate their suitability for translational research. Soft grids with 0.2 to 10 mm electrode pitch and diameter are embedded in 150 µm silicone membranes. The soft grids are compatible with surgical handling and can be folded to safely interface hidden cerebral surface such as the Sylvian fold in human cadaveric models. It is found that the thin-film conductor grids do not generate diagnostic-impeding imaging artefacts (<1 mm) nor adverse local heating within a standard 3T clinical magnetic resonance imaging scanner. Next, the ability of the soft grids to record subdural neural activity in minipigs acutely and two weeks postimplantation is validated. Taken together, these results suggest a promising future alternative to current stiff electrodes and may enable the future adoption of soft ECoG grids in translational research and ultimately in clinical settings.
Keywords
General Engineering, General Physics and Astronomy, General Materials Science, Medicine (miscellaneous), General Chemical Engineering, Biochemistry, Genetics and Molecular Biology (miscellaneous), MRI compatibility, electrocorticography, neural implants, soft electrodes, translational research
Pubmed
Web of science
Open Access
Yes
Create date
03/04/2021 10:14
Last modification date
08/07/2021 6:37
Usage data