Cocaine inverts rules for synaptic plasticity of glutamate transmission in the ventral tegmental area.

Details

Serval ID
serval:BIB_53553CCE1C18
Type
Article: article from journal or magazin.
Collection
Publications
Title
Cocaine inverts rules for synaptic plasticity of glutamate transmission in the ventral tegmental area.
Journal
Nature neuroscience
Author(s)
Mameli M., Bellone C., Brown M.T., Lüscher C.
ISSN
1546-1726 (Electronic)
ISSN-L
1097-6256
Publication state
Published
Issued date
04/2011
Peer-reviewed
Oui
Volume
14
Number
4
Pages
414-416
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Abstract
The manner in which drug-evoked synaptic plasticity affects reward circuits remains largely elusive. We found that cocaine reduced NMDA receptor excitatory postsynaptic currents and inserted GluA2-lacking AMPA receptors in dopamine neurons of mice. Consequently, a stimulation protocol pairing glutamate release with hyperpolarizing current injections further strengthened synapses after cocaine treatment. Our data suggest that early cocaine-evoked plasticity in the ventral tegmental area inverts the rules for activity-dependent plasticity, eventually leading to addictive behavior.

Keywords
Animals, Cocaine/pharmacology, Cocaine-Related Disorders/genetics, Cocaine-Related Disorders/metabolism, Cocaine-Related Disorders/physiopathology, Disease Models, Animal, Dopamine Uptake Inhibitors/pharmacology, Glutamic Acid/physiology, Mice, Neuronal Plasticity/drug effects, Neuronal Plasticity/physiology, Organ Culture Techniques, Synaptic Transmission/drug effects, Synaptic Transmission/physiology, Ventral Tegmental Area/drug effects, Ventral Tegmental Area/metabolism, Ventral Tegmental Area/physiopathology
Pubmed
Web of science
Create date
31/01/2017 15:22
Last modification date
20/08/2019 14:08
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