Cocaine inverts rules for synaptic plasticity of glutamate transmission in the ventral tegmental area.
Détails
ID Serval
serval:BIB_53553CCE1C18
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Cocaine inverts rules for synaptic plasticity of glutamate transmission in the ventral tegmental area.
Périodique
Nature neuroscience
ISSN
1546-1726 (Electronic)
ISSN-L
1097-6256
Statut éditorial
Publié
Date de publication
04/2011
Peer-reviewed
Oui
Volume
14
Numéro
4
Pages
414-416
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Publication Status: ppublish
Résumé
The manner in which drug-evoked synaptic plasticity affects reward circuits remains largely elusive. We found that cocaine reduced NMDA receptor excitatory postsynaptic currents and inserted GluA2-lacking AMPA receptors in dopamine neurons of mice. Consequently, a stimulation protocol pairing glutamate release with hyperpolarizing current injections further strengthened synapses after cocaine treatment. Our data suggest that early cocaine-evoked plasticity in the ventral tegmental area inverts the rules for activity-dependent plasticity, eventually leading to addictive behavior.
Mots-clé
Animals, Cocaine/pharmacology, Cocaine-Related Disorders/genetics, Cocaine-Related Disorders/metabolism, Cocaine-Related Disorders/physiopathology, Disease Models, Animal, Dopamine Uptake Inhibitors/pharmacology, Glutamic Acid/physiology, Mice, Neuronal Plasticity/drug effects, Neuronal Plasticity/physiology, Organ Culture Techniques, Synaptic Transmission/drug effects, Synaptic Transmission/physiology, Ventral Tegmental Area/drug effects, Ventral Tegmental Area/metabolism, Ventral Tegmental Area/physiopathology
Pubmed
Web of science
Création de la notice
31/01/2017 16:22
Dernière modification de la notice
20/08/2019 15:08