Pregnancy after breast cancer: Are young patients willing to participate in clinical studies?

Details

Serval ID
serval:BIB_530C97E722B3
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Pregnancy after breast cancer: Are young patients willing to participate in clinical studies?
Journal
Breast
Author(s)
Pagani O., Ruggeri M., Manunta S., Saunders C., Peccatori F., Cardoso F., Kaufman B., Paluch-Shimon S., Gewefel H., Gallerani E., Abulkhair O.M., Pistilli B., Warner E., Saloustros E., Perey L., Zaman K., Rabaglio M., Gelber S., Gelber R.D., Goldhirsch A., Korde L., Azim H.A., Partridge A.H.
ISSN
1532-3080 (Electronic)
ISSN-L
0960-9776
Publication state
Published
Issued date
2015
Peer-reviewed
Oui
Volume
24
Number
3
Pages
201-207
Language
english
Abstract
Young patients with breast cancer (BC) are often concerned about treatment-induced infertility and express maternity desire. Conception after BC does not seem to affect outcome, but information in estrogen-receptor positive (ER+) disease is not definitive. From September 2012-March 2013, 212 evaluable patients with ER+ early BC, <37 years at diagnosis, from 5 regions (Europe/US/Canada/Middle-East/Australia) answered a survey about fertility concerns, maternity desire and interest in a study of endocrine therapy (ET) interruption to allow pregnancy. Overall, 37% of respondents were interested in the study; younger patients (≤30 years) reported higher interest (57%). Motivation in younger patients treated >30 months was higher (83%) than in older women (14%), interest was independent of age in patients treated for ≤30 months. A prospective study in this patient population seems relevant and feasible. The International-Breast-Cancer-Study-Group (IBCSG), within the Breast-International-Group (BIG) - North-American-Breast-Cancer-Groups (NABCG) collaboration, is launching a study (POSITIVE) addressing ET interruption to allow pregnancy.
Keywords
Adult, Age Factors, Breast Neoplasms/chemistry, Breast Neoplasms/drug therapy, Clinical Trials as Topic/psychology, Feasibility Studies, Female, Fertility Preservation/methods, Fertility Preservation/psychology, Humans, Patient Participation/psychology, Pregnancy, Pregnancy Complications, Neoplastic/drug therapy, Pregnancy Complications, Neoplastic/pathology, Receptors, Estrogen, Surveys and Questionnaires, Withholding Treatment
Pubmed
Create date
04/02/2016 22:17
Last modification date
20/08/2019 14:08
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