Ionotropic Receptor-dependent moist and dry cells control hygrosensation in Drosophila.

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State: Public
Version: Final published version
Serval ID
serval:BIB_53097AE12AE5
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Ionotropic Receptor-dependent moist and dry cells control hygrosensation in Drosophila.
Journal
eLife
Author(s)
Knecht Z.A., Silbering A.F., Cruz J., Yang L., Croset V., Benton R., Garrity P.A.
ISSN
2050-084X (Electronic)
ISSN-L
2050-084X
Publication state
Published
Issued date
16/06/2017
Peer-reviewed
Oui
Volume
6
Pages
e26654
Language
english
Notes
Publication types: Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
Publication Status: epublish
Abstract
Insects use hygrosensation (humidity sensing) to avoid desiccation and, in vectors such as mosquitoes, to locate vertebrate hosts. Sensory neurons activated by either dry or moist air ('dry cells' and 'moist cells') have been described in many insects, but their behavioral roles and the molecular basis of their hygrosensitivity remain unclear. We recently reported that <i>Drosophila</i> hygrosensation relies on three Ionotropic Receptors (IRs) required for dry cell function: IR25a, IR93a and IR40a (Knecht et al., 2016). Here, we discover <i>Drosophila</i> moist cells and show that they require IR25a and IR93a together with IR68a, a conserved, but orphan IR. Both IR68a- and IR40a-dependent pathways drive hygrosensory behavior: each is important for dry-seeking by hydrated flies and together they underlie moist-seeking by dehydrated flies. These studies reveal that humidity sensing in <i>Drosophila</i> , and likely other insects, involves the combined activity of two molecularly related but neuronally distinct hygrosensing systems.
Keywords
Animals, Behavior, Animal, Drosophila/physiology, Drosophila Proteins/metabolism, Humidity, Receptors, Ionotropic Glutamate/metabolism, Sensory Receptor Cells/physiology, D. melanogaster, IR25a, desiccation, humidity, humidity sensing, iGluR, neuroscience, sensory transduction
Pubmed
Web of science
Open Access
Yes
Create date
27/06/2017 17:35
Last modification date
20/08/2019 15:08
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